Interferon-stimulated genes: Roles in viral pathogenesis

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalCurrent Opinion in Virology
Volume6
Issue number1
DOIs
StatePublished - 2014

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Interferons
Virus Diseases
Genes
Viral Genes
Knockout Mice
Antiviral Agents

ASJC Scopus subject areas

  • Virology
  • Medicine(all)

Cite this

Interferon-stimulated genes : Roles in viral pathogenesis. / Schoggins, John W.

In: Current Opinion in Virology, Vol. 6, No. 1, 2014, p. 40-46.

Research output: Contribution to journalArticle

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