Interferon-stimulated genes: Roles in viral pathogenesis

John W. Schoggins

doi:10.1016/j.coviro.2014.03.006

Interferon-stimulated genes: Roles in viral pathogenesis

John W. Schoggins

Research output: Contribution to journal › Review article › peer-review

219 Scopus citations

Abstract

Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.

Original language	English (US)
Pages (from-to)	40-46
Number of pages	7
Journal	Current Opinion in Virology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.coviro.2014.03.006
State	Published - Jun 2014

ASJC Scopus subject areas

Virology

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10.1016/j.coviro.2014.03.006

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title = "Interferon-stimulated genes: Roles in viral pathogenesis",

abstract = "Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.",

author = "Schoggins, {John W.}",

note = "Funding Information: This work was funded in part by NIH Grant DK095031 . I thank Neal Alto for a critical reading of the manuscript.",

year = "2014",

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N2 - Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.

AB - Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.

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Interferon-stimulated genes: Roles in viral pathogenesis

Abstract

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