Interferon-stimulated genes: Roles in viral pathogenesis

Research output: Contribution to journalReview article

129 Scopus citations

Abstract

Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalCurrent Opinion in Virology
Volume6
Issue number1
DOIs
StatePublished - Jun 2014

ASJC Scopus subject areas

  • Virology

Fingerprint Dive into the research topics of 'Interferon-stimulated genes: Roles in viral pathogenesis'. Together they form a unique fingerprint.

  • Cite this