Interleukin-1 in human skin: Dysregulation in psoriasis

Kevin D. Cooper, Craig Hammerberg, Ole Baadsgaard, J. T. Elder, Lawrence S. Chan, Robert S. Taylor, John J. Voorhees, Gary Fisher

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Cytokine dysregulation is an attractive concept to explain many of the observed abnormalities in psoriasis. IL-1, in particular, can potentiate immune cellular activation, activate fibroblasts, and increase endothelial cell adhesiveness to leukocytes. Here, we review IL-1 regulation in normal and psoriatic skin in vivo in relation to normal skin and cultured keratinocytes. Contrary to expectations, IL-1 functional activity in psoriatic lesions is reduced, not increased, relative to normal skin. The reduction is attributable to the presence of IL-1 inhibitors, reduced IL-lα levels, and an IL-1β that lacked function in T-cell assays. IL-1β protein is actually significantly increased in non-functionality remains unclear. Unlike cultured keratinocytes, which accumulate large, inactive IL-1β precursors, both normal and psoriatic skin process IL-1β to a mature form. Novel mechanisms of post-translational processing by epidermis in vivo may generate a novel form of IL-1β with unknown functions. The marked abnormalities of IL-1 regulation in psoriatic skin suggest that this molecule may be important in normal skin homeostasis.

Original languageEnglish (US)
Pages (from-to)S24-S26
JournalJournal of Investigative Dermatology
Volume95
Issue number5
DOIs
StatePublished - Nov 1990

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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    Cooper, K. D., Hammerberg, C., Baadsgaard, O., Elder, J. T., Chan, L. S., Taylor, R. S., Voorhees, J. J., & Fisher, G. (1990). Interleukin-1 in human skin: Dysregulation in psoriasis. Journal of Investigative Dermatology, 95(5), S24-S26. https://doi.org/10.1111/1523-1747.ep12505698