Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia

H. S A Oldenburg, M. Burress Welborn, J. H. Pruitt, P. G. Boelens, J. M. Seeger, T. D. Martin, R. I C Wesdorp, J. A. Rauwerda, P. A M Van Leeuwen, L. L. Moldawer

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Objectives: To evaluate the plasma IL-10 levels during elective operative repair of thoraco-abdominal and abdominal aortic aneurysm repair. To study whether IL-10 plasma levels are associated with the duration of cross-clamping (ischaemia) and clinical outcome. Materials: Fifteen consecutive patients undergoing surgery for TAAA and 10 consecutive patients undergoing surgical repair of AAA were included. Methods: Plasma concentrations of IL-10 were measured by ELISA technique. Clinical outcome of the TAAA patients was prospectively analysed. Results: during aortic clamping IL-10 was produced in both populations. The plasma IL-10 peak (934 ±172 pg/ml) of the TAAA group was seen at 4 h after declamping and remained detectable after 48 h. The plasma IL-10 peak (212 ± 32 pg/ml) of the AAA group was seen 30 min after declamping and fell to undetectable levels by 24 h. These data show that the peak IL-10 plasma levels in TAAA repair are significantly (p<0.05) higher compared to the peak IL-10 plasma levels as seen during AAA repair. A positive correlation was seen between cross-clamping and peak plasma IL-10 and organ dysfunction. Conclusions: IL-10 plasma concentrations appear higher, later and are longer detectable in patients undergoing TAAA. Correlations were seen with duration of cross-clamping and MSOD.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume20
Issue number2
DOIs
StatePublished - Jan 1 2000

Keywords

  • Aortic aneurysm
  • IL-10
  • Visceral ischaemia

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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    Oldenburg, H. S. A., Burress Welborn, M., Pruitt, J. H., Boelens, P. G., Seeger, J. M., Martin, T. D., Wesdorp, R. I. C., Rauwerda, J. A., Van Leeuwen, P. A. M., & Moldawer, L. L. (2000). Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia. European Journal of Vascular and Endovascular Surgery, 20(2), 169-172. https://doi.org/10.1053/ejvs.2000.1147