Abstract
Objectives: To evaluate the plasma IL-10 levels during elective operative repair of thoraco-abdominal and abdominal aortic aneurysm repair. To study whether IL-10 plasma levels are associated with the duration of cross-clamping (ischaemia) and clinical outcome. Materials: Fifteen consecutive patients undergoing surgery for TAAA and 10 consecutive patients undergoing surgical repair of AAA were included. Methods: Plasma concentrations of IL-10 were measured by ELISA technique. Clinical outcome of the TAAA patients was prospectively analysed. Results: during aortic clamping IL-10 was produced in both populations. The plasma IL-10 peak (934 ±172 pg/ml) of the TAAA group was seen at 4 h after declamping and remained detectable after 48 h. The plasma IL-10 peak (212 ± 32 pg/ml) of the AAA group was seen 30 min after declamping and fell to undetectable levels by 24 h. These data show that the peak IL-10 plasma levels in TAAA repair are significantly (p<0.05) higher compared to the peak IL-10 plasma levels as seen during AAA repair. A positive correlation was seen between cross-clamping and peak plasma IL-10 and organ dysfunction. Conclusions: IL-10 plasma concentrations appear higher, later and are longer detectable in patients undergoing TAAA. Correlations were seen with duration of cross-clamping and MSOD.
Original language | English (US) |
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Pages (from-to) | 169-172 |
Number of pages | 4 |
Journal | European Journal of Vascular and Endovascular Surgery |
Volume | 20 |
Issue number | 2 |
DOIs | |
State | Published - 2000 |
Keywords
- Aortic aneurysm
- IL-10
- Visceral ischaemia
ASJC Scopus subject areas
- Surgery
- Cardiology and Cardiovascular Medicine