Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia

H. S A Oldenburg, M. Burress Welborn, J. H. Pruitt, P. G. Boelens, J. M. Seeger, T. D. Martin, R. I C Wesdorp, J. A. Rauwerda, P. A M Van Leeuwen, L. L. Moldawer

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objectives: To evaluate the plasma IL-10 levels during elective operative repair of thoraco-abdominal and abdominal aortic aneurysm repair. To study whether IL-10 plasma levels are associated with the duration of cross-clamping (ischaemia) and clinical outcome. Materials: Fifteen consecutive patients undergoing surgery for TAAA and 10 consecutive patients undergoing surgical repair of AAA were included. Methods: Plasma concentrations of IL-10 were measured by ELISA technique. Clinical outcome of the TAAA patients was prospectively analysed. Results: during aortic clamping IL-10 was produced in both populations. The plasma IL-10 peak (934 ±172 pg/ml) of the TAAA group was seen at 4 h after declamping and remained detectable after 48 h. The plasma IL-10 peak (212 ± 32 pg/ml) of the AAA group was seen 30 min after declamping and fell to undetectable levels by 24 h. These data show that the peak IL-10 plasma levels in TAAA repair are significantly (p<0.05) higher compared to the peak IL-10 plasma levels as seen during AAA repair. A positive correlation was seen between cross-clamping and peak plasma IL-10 and organ dysfunction. Conclusions: IL-10 plasma concentrations appear higher, later and are longer detectable in patients undergoing TAAA. Correlations were seen with duration of cross-clamping and MSOD.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume20
Issue number2
DOIs
StatePublished - 2000

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Abdominal Aortic Aneurysm
Interleukin-10
Ischemia
Constriction
Enzyme-Linked Immunosorbent Assay

Keywords

  • Aortic aneurysm
  • IL-10
  • Visceral ischaemia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Surgery

Cite this

Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia. / Oldenburg, H. S A; Burress Welborn, M.; Pruitt, J. H.; Boelens, P. G.; Seeger, J. M.; Martin, T. D.; Wesdorp, R. I C; Rauwerda, J. A.; Van Leeuwen, P. A M; Moldawer, L. L.

In: European Journal of Vascular and Endovascular Surgery, Vol. 20, No. 2, 2000, p. 169-172.

Research output: Contribution to journalArticle

Oldenburg, HSA, Burress Welborn, M, Pruitt, JH, Boelens, PG, Seeger, JM, Martin, TD, Wesdorp, RIC, Rauwerda, JA, Van Leeuwen, PAM & Moldawer, LL 2000, 'Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia', European Journal of Vascular and Endovascular Surgery, vol. 20, no. 2, pp. 169-172. https://doi.org/10.1053/ejvs.2000.1147
Oldenburg, H. S A ; Burress Welborn, M. ; Pruitt, J. H. ; Boelens, P. G. ; Seeger, J. M. ; Martin, T. D. ; Wesdorp, R. I C ; Rauwerda, J. A. ; Van Leeuwen, P. A M ; Moldawer, L. L. / Interleukin-10 appearance following thoraco-abdominal and abdominal aortic aneurysm repair is associated with the duration of visceral ischaemia. In: European Journal of Vascular and Endovascular Surgery. 2000 ; Vol. 20, No. 2. pp. 169-172.
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AU - Oldenburg, H. S A

AU - Burress Welborn, M.

AU - Pruitt, J. H.

AU - Boelens, P. G.

AU - Seeger, J. M.

AU - Martin, T. D.

AU - Wesdorp, R. I C

AU - Rauwerda, J. A.

AU - Van Leeuwen, P. A M

AU - Moldawer, L. L.

PY - 2000

Y1 - 2000

N2 - Objectives: To evaluate the plasma IL-10 levels during elective operative repair of thoraco-abdominal and abdominal aortic aneurysm repair. To study whether IL-10 plasma levels are associated with the duration of cross-clamping (ischaemia) and clinical outcome. Materials: Fifteen consecutive patients undergoing surgery for TAAA and 10 consecutive patients undergoing surgical repair of AAA were included. Methods: Plasma concentrations of IL-10 were measured by ELISA technique. Clinical outcome of the TAAA patients was prospectively analysed. Results: during aortic clamping IL-10 was produced in both populations. The plasma IL-10 peak (934 ±172 pg/ml) of the TAAA group was seen at 4 h after declamping and remained detectable after 48 h. The plasma IL-10 peak (212 ± 32 pg/ml) of the AAA group was seen 30 min after declamping and fell to undetectable levels by 24 h. These data show that the peak IL-10 plasma levels in TAAA repair are significantly (p<0.05) higher compared to the peak IL-10 plasma levels as seen during AAA repair. A positive correlation was seen between cross-clamping and peak plasma IL-10 and organ dysfunction. Conclusions: IL-10 plasma concentrations appear higher, later and are longer detectable in patients undergoing TAAA. Correlations were seen with duration of cross-clamping and MSOD.

AB - Objectives: To evaluate the plasma IL-10 levels during elective operative repair of thoraco-abdominal and abdominal aortic aneurysm repair. To study whether IL-10 plasma levels are associated with the duration of cross-clamping (ischaemia) and clinical outcome. Materials: Fifteen consecutive patients undergoing surgery for TAAA and 10 consecutive patients undergoing surgical repair of AAA were included. Methods: Plasma concentrations of IL-10 were measured by ELISA technique. Clinical outcome of the TAAA patients was prospectively analysed. Results: during aortic clamping IL-10 was produced in both populations. The plasma IL-10 peak (934 ±172 pg/ml) of the TAAA group was seen at 4 h after declamping and remained detectable after 48 h. The plasma IL-10 peak (212 ± 32 pg/ml) of the AAA group was seen 30 min after declamping and fell to undetectable levels by 24 h. These data show that the peak IL-10 plasma levels in TAAA repair are significantly (p<0.05) higher compared to the peak IL-10 plasma levels as seen during AAA repair. A positive correlation was seen between cross-clamping and peak plasma IL-10 and organ dysfunction. Conclusions: IL-10 plasma concentrations appear higher, later and are longer detectable in patients undergoing TAAA. Correlations were seen with duration of cross-clamping and MSOD.

KW - Aortic aneurysm

KW - IL-10

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