Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes

M. E. Richardson, C. Quanguang, D. A. Filippa, K. Offit, A. Hampton, P. R K Koduru, S. C. Jhanwar, P. H. Lieberman, B. D. Clarkson, R. S K Chaganti

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Abstract

We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin's lymphoma (NHL) bearing (t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1, 1984, to December 31, 1986. These included seven cases that had histological evidence of transformation from a lower grade and 11 that lacked such evidence. The most common of the additional changes seen in both groups affected chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and the presence of more than two copies of chromosome 7 or duplication of 7q. Changes affecting these two chromosomes were less frequent in low-grade lymphomas with t(14;18) as well as in lymphomas lacking the translocation. These data suggest that common cytogenetic mechanisms underlie expression of high-grade histologies by lymphomas carrying (t14;18). In addition, they may serve as indicators of transformation when encountered in low-grade lymphomas with t(14;18).

Original languageEnglish (US)
Pages (from-to)444-447
Number of pages4
JournalBlood
Volume70
Issue number2
StatePublished - 1987

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Histology
Chromosomes
Non-Hodgkin's Lymphoma
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7
Cytogenetics
Lymphoma
Bearings (structural)
Chromosome Duplication
Chromosome Aberrations
Prospective Studies

ASJC Scopus subject areas

  • Hematology

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Richardson, M. E., Quanguang, C., Filippa, D. A., Offit, K., Hampton, A., Koduru, P. R. K., ... Chaganti, R. S. K. (1987). Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes. Blood, 70(2), 444-447.

Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes. / Richardson, M. E.; Quanguang, C.; Filippa, D. A.; Offit, K.; Hampton, A.; Koduru, P. R K; Jhanwar, S. C.; Lieberman, P. H.; Clarkson, B. D.; Chaganti, R. S K.

In: Blood, Vol. 70, No. 2, 1987, p. 444-447.

Research output: Contribution to journalArticle

Richardson, ME, Quanguang, C, Filippa, DA, Offit, K, Hampton, A, Koduru, PRK, Jhanwar, SC, Lieberman, PH, Clarkson, BD & Chaganti, RSK 1987, 'Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes', Blood, vol. 70, no. 2, pp. 444-447.
Richardson, M. E. ; Quanguang, C. ; Filippa, D. A. ; Offit, K. ; Hampton, A. ; Koduru, P. R K ; Jhanwar, S. C. ; Lieberman, P. H. ; Clarkson, B. D. ; Chaganti, R. S K. / Intermediate- to high-grade histology of lymphomas carrying t(14;18) is associated with additional nonrandom chromosome changes. In: Blood. 1987 ; Vol. 70, No. 2. pp. 444-447.
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abstract = "We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin's lymphoma (NHL) bearing (t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1, 1984, to December 31, 1986. These included seven cases that had histological evidence of transformation from a lower grade and 11 that lacked such evidence. The most common of the additional changes seen in both groups affected chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and the presence of more than two copies of chromosome 7 or duplication of 7q. Changes affecting these two chromosomes were less frequent in low-grade lymphomas with t(14;18) as well as in lymphomas lacking the translocation. These data suggest that common cytogenetic mechanisms underlie expression of high-grade histologies by lymphomas carrying (t14;18). In addition, they may serve as indicators of transformation when encountered in low-grade lymphomas with t(14;18).",
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AU - Richardson, M. E.

AU - Quanguang, C.

AU - Filippa, D. A.

AU - Offit, K.

AU - Hampton, A.

AU - Koduru, P. R K

AU - Jhanwar, S. C.

AU - Lieberman, P. H.

AU - Clarkson, B. D.

AU - Chaganti, R. S K

PY - 1987

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N2 - We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin's lymphoma (NHL) bearing (t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1, 1984, to December 31, 1986. These included seven cases that had histological evidence of transformation from a lower grade and 11 that lacked such evidence. The most common of the additional changes seen in both groups affected chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and the presence of more than two copies of chromosome 7 or duplication of 7q. Changes affecting these two chromosomes were less frequent in low-grade lymphomas with t(14;18) as well as in lymphomas lacking the translocation. These data suggest that common cytogenetic mechanisms underlie expression of high-grade histologies by lymphomas carrying (t14;18). In addition, they may serve as indicators of transformation when encountered in low-grade lymphomas with t(14;18).

AB - We describe additional nonrandom chromosome abnormalities in 18 cases of intermediate- to high-grade non-Hodgkin's lymphoma (NHL) bearing (t(14;18) that were ascertained in a prospective cytogenetic study of all lymphomas seen at Memorial Hospital during the period January 1, 1984, to December 31, 1986. These included seven cases that had histological evidence of transformation from a lower grade and 11 that lacked such evidence. The most common of the additional changes seen in both groups affected chromosomes 6 and 7 and comprised the loss of chromosome 6 or del(6q) and the presence of more than two copies of chromosome 7 or duplication of 7q. Changes affecting these two chromosomes were less frequent in low-grade lymphomas with t(14;18) as well as in lymphomas lacking the translocation. These data suggest that common cytogenetic mechanisms underlie expression of high-grade histologies by lymphomas carrying (t14;18). In addition, they may serve as indicators of transformation when encountered in low-grade lymphomas with t(14;18).

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