Internalization of ionotropic glutamate receptors in response to mGluR activation

Eric M. Snyder, Benjamin D. Philpot, Kimberly M. Huber, Xin Dong, Justin R. Fallon, Mark F. Bear

Research output: Contribution to journalArticlepeer-review

437 Scopus citations

Abstract

Activation of group 1 metabotropic glutamate receptors (mGluRs) stimulates dendritic protein synthesis and long-term synaptic depression (LTD), but it remains unclear how these effects are related. Here we provide evidence that a consequence of mGluR activation in the hippocampus is the rapid loss of both AMPA and NMDA receptors from synapses. Like mGluR-LTD, the stable expression of this change requires protein synthesis. These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking.

Original languageEnglish (US)
Pages (from-to)1079-1085
Number of pages7
JournalNature neuroscience
Volume4
Issue number11
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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