International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Evan S. Dellon, Nirmala Gonsalves, J. Pablo Abonia, Jeffrey A. Alexander, Nicoleta C. Arva, Dan Atkins, Stephen E. Attwood, Marcus K.H. Auth, Dominique D. Bailey, Luc Biederman, Carine Blanchard, Peter A. Bonis, Paroma Bose, Albert J. Bredenoord, Joy W. Chang, Mirna Chehade, Margaret H. Collins, Carlo Di Lorenzo, Jorge Amil Dias, Ranjan DohilChristophe Dupont, Gary W. Falk, Cristina T. Ferreira, Adam T. Fox, Robert M Genta, Thomas Greuter, Sandeep K. Gupta, Ikuo Hirano, Girish S. Hiremath, Jennifer L. Horsley-Silva, Shunji Ishihara, Norihisa Ishimura, Elizabeth T. Jensen, Carolina Gutiérrez-Junquera, David A. Katzka, Paneez Khoury, Yoshikazu Kinoshita, Kara L. Kliewer, Sibylle Koletzko, John Leung, Chris A. Liacouras, Alfredo J. Lucendo, Lisa J. Martin, Emily C. McGowan, Calies Menard-Katcher, David C. Metz, Talya L. Miller, Fouad J. Moawad, Amanda B. Muir, Vincent A. Mukkada, Simon Murch, Quan M. Nhu, Ichiro Nomura, Samuel Nurko, Yoshikazu Ohtsuka, Salvatore Oliva, Rok Orel, Alexandra Papadopoulou, Dhyanesh A. Patel, Robert D. Pesek, Kathryn A. Peterson, Hamish Philpott, Philip E. Putnam, Joel E. Richter, Rachel Rosen, Melanie A. Ruffner, Ekaterina Safroneeva, Philipp Schreiner, Alain Schoepfer, Shauna R. Schroeder, Neil Shah, Rhonda F. Souza, Stuart J. Spechler, Jonathan M. Spergel, Alex Straumann, Nicholas J. Talley, Nikhil Thapar, Yvan Vandenplas, Rajitha D. Venkatesh, Mario C. Vieira, Ulrike von Arnim, Marjorie M. Walker, Joshua B. Wechsler, Barry K. Wershil, Benjamin L. Wright, Yoshiyuki Yamada, Guang Yu Yang, Noam Zevit, Marc E. Rothenberg, Glenn T. Furuta, Seema S. Aceves

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background & Aims: Substantial heterogeneity in terminology used for eosinophilic gastrointestinal diseases (EGIDs), particularly the catchall term “eosinophilic gastroenteritis,” limits clinical and research advances. We aimed to achieve an international consensus for standardized EGID nomenclature. Methods: This consensus process utilized Delphi methodology. An initial naming framework was proposed and refined in iterative fashion, then assessed in a first round of Delphi voting. Results were discussed in 2 consensus meetings, and the framework was updated and reassessed in a second Delphi vote, with a 70% threshold set for agreement. Results: Of 91 experts participating, 85 (93%) completed the first and 82 (90%) completed the second Delphi surveys. Consensus was reached on all but 2 statements. “EGID” was the preferred umbrella term for disorders of gastrointestinal (GI) tract eosinophilic inflammation in the absence of secondary causes (100% agreement). Involved GI tract segments will be named specifically and use an “Eo” abbreviation convention: eosinophilic gastritis (now abbreviated EoG), eosinophilic enteritis (EoN), and eosinophilic colitis (EoC). The term “eosinophilic gastroenteritis” is no longer preferred as the overall name (96% agreement). When >2 GI tract areas are involved, the name should reflect all of the involved areas. Conclusions: This international process resulted in consensus for updated EGID nomenclature for both clinical and research use. EGID will be the umbrella term, rather than “eosinophilic gastroenteritis,” and specific naming conventions by location of GI tract involvement are recommended. As more data are developed, this framework can be updated to reflect best practices and the underlying science.

Original languageEnglish (US)
JournalClinical Gastroenterology and Hepatology
DOIs
StateAccepted/In press - 2022
Externally publishedYes

Keywords

  • Classification
  • Delphi
  • Eosinophilic Gastroenteritis
  • Eosinophilic Gastrointestinal Disease
  • Nomenclature

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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