International Consensus Statement on Allergy and Rhinology

Allergic Rhinitis

Sarah K. Wise, Sandra Y. Lin, Elina Toskala, Richard R. Orlandi, Cezmi A. Akdis, Jeremiah A. Alt, Antoine Azar, Fuad M. Baroody, Claus Bachert, G. Walter Canonica, Thomas Chacko, Cemal Cingi, Giorgio Ciprandi, Jacquelynne Corey, Linda S. Cox, Peter Socrates Creticos, Adnan Custovic, Cecelia Damask, Adam DeConde, John M. DelGaudio & 52 others Charles S. Ebert, Jean Anderson Eloy, Carrie E. Flanagan, Wytske J. Fokkens, Christine Franzese, Jan Gosepath, Ashleigh Halderman, Robert G. Hamilton, Hans Jürgen Hoffman, Jens M. Hohlfeld, Steven M. Houser, Peter H. Hwang, Cristoforo Incorvaia, Deborah Jarvis, Ayesha N. Khalid, Maritta Kilpeläinen, Todd T. Kingdom, Helene Krouse, Desiree Larenas-Linnemann, Adrienne M. Laury, Stella E. Lee, Joshua M. Levy, Amber U. Luong, Bradley F. Marple, Edward D. McCoul, K. Christopher McMains, Erik Melén, James W. Mims, Gianna Moscato, Joaquim Mullol, Harold S. Nelson, Monica Patadia, Ruby Pawankar, Oliver Pfaar, Michael P. Platt, William Reisacher, Carmen Rondón, Luke Rudmik, Matthew Ryan, Joaquin Sastre, Rodney J. Schlosser, Russell A. Settipane, Hemant P. Sharma, Aziz Sheikh, Timothy L. Smith, Pongsakorn Tantilipikorn, Jody R. Tversky, Maria C. Veling, De Yun Wang, Marit Westman, Magnus Wickman, Mark Zacharek

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). Methods: Using previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus. Results: The ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR. Conclusion: This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.

Original languageEnglish (US)
Pages (from-to)108-352
Number of pages245
JournalInternational Forum of Allergy and Rhinology
Volume8
Issue number2
DOIs
StatePublished - Feb 1 2018

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Hypersensitivity
Allergic Rhinitis
Comorbidity
Epidemiology
Medicine

Keywords

  • allergen extract
  • allergen immunotherapy
  • allergic rhinitis
  • allergy
  • antihistamine
  • asthma
  • atopic dermatitis
  • avoidance
  • biologic
  • cockroach
  • conjunctivitis
  • consensus
  • corticosteroid
  • cough
  • cromolyn
  • decongestant
  • environment
  • eosinophilic esophagitis
  • epicutaneous immunotherapy
  • epidemiology
  • evidence-based medicine
  • food allergy
  • genetics
  • house dust mite
  • IgE
  • immunoglobulin E
  • immunotherapy
  • inhalant allergy
  • leukotriene
  • microbiome
  • occupational rhinitis
  • omalizumab
  • pathophysiology
  • perennial
  • pet dander
  • pollen
  • probiotic
  • quality of life
  • rhinitis
  • rhinitis
  • rhinosinusitis
  • risk factor
  • saline
  • seasonal
  • sensitization
  • sinusitis
  • sleep
  • socioeconomic
  • specific IgE
  • subcutaneous immunotherapy
  • sublingual immunotherapy
  • systematic review
  • total IgE
  • transcutaneous immunotherapy
  • validated survey

ASJC Scopus subject areas

  • Immunology and Allergy
  • Otorhinolaryngology

Cite this

Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., ... Zacharek, M. (2018). International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. International Forum of Allergy and Rhinology, 8(2), 108-352. https://doi.org/10.1002/alr.22073

International Consensus Statement on Allergy and Rhinology : Allergic Rhinitis. / Wise, Sarah K.; Lin, Sandra Y.; Toskala, Elina; Orlandi, Richard R.; Akdis, Cezmi A.; Alt, Jeremiah A.; Azar, Antoine; Baroody, Fuad M.; Bachert, Claus; Canonica, G. Walter; Chacko, Thomas; Cingi, Cemal; Ciprandi, Giorgio; Corey, Jacquelynne; Cox, Linda S.; Creticos, Peter Socrates; Custovic, Adnan; Damask, Cecelia; DeConde, Adam; DelGaudio, John M.; Ebert, Charles S.; Eloy, Jean Anderson; Flanagan, Carrie E.; Fokkens, Wytske J.; Franzese, Christine; Gosepath, Jan; Halderman, Ashleigh; Hamilton, Robert G.; Hoffman, Hans Jürgen; Hohlfeld, Jens M.; Houser, Steven M.; Hwang, Peter H.; Incorvaia, Cristoforo; Jarvis, Deborah; Khalid, Ayesha N.; Kilpeläinen, Maritta; Kingdom, Todd T.; Krouse, Helene; Larenas-Linnemann, Desiree; Laury, Adrienne M.; Lee, Stella E.; Levy, Joshua M.; Luong, Amber U.; Marple, Bradley F.; McCoul, Edward D.; McMains, K. Christopher; Melén, Erik; Mims, James W.; Moscato, Gianna; Mullol, Joaquim; Nelson, Harold S.; Patadia, Monica; Pawankar, Ruby; Pfaar, Oliver; Platt, Michael P.; Reisacher, William; Rondón, Carmen; Rudmik, Luke; Ryan, Matthew; Sastre, Joaquin; Schlosser, Rodney J.; Settipane, Russell A.; Sharma, Hemant P.; Sheikh, Aziz; Smith, Timothy L.; Tantilipikorn, Pongsakorn; Tversky, Jody R.; Veling, Maria C.; Wang, De Yun; Westman, Marit; Wickman, Magnus; Zacharek, Mark.

In: International Forum of Allergy and Rhinology, Vol. 8, No. 2, 01.02.2018, p. 108-352.

Research output: Contribution to journalArticle

Wise, SK, Lin, SY, Toskala, E, Orlandi, RR, Akdis, CA, Alt, JA, Azar, A, Baroody, FM, Bachert, C, Canonica, GW, Chacko, T, Cingi, C, Ciprandi, G, Corey, J, Cox, LS, Creticos, PS, Custovic, A, Damask, C, DeConde, A, DelGaudio, JM, Ebert, CS, Eloy, JA, Flanagan, CE, Fokkens, WJ, Franzese, C, Gosepath, J, Halderman, A, Hamilton, RG, Hoffman, HJ, Hohlfeld, JM, Houser, SM, Hwang, PH, Incorvaia, C, Jarvis, D, Khalid, AN, Kilpeläinen, M, Kingdom, TT, Krouse, H, Larenas-Linnemann, D, Laury, AM, Lee, SE, Levy, JM, Luong, AU, Marple, BF, McCoul, ED, McMains, KC, Melén, E, Mims, JW, Moscato, G, Mullol, J, Nelson, HS, Patadia, M, Pawankar, R, Pfaar, O, Platt, MP, Reisacher, W, Rondón, C, Rudmik, L, Ryan, M, Sastre, J, Schlosser, RJ, Settipane, RA, Sharma, HP, Sheikh, A, Smith, TL, Tantilipikorn, P, Tversky, JR, Veling, MC, Wang, DY, Westman, M, Wickman, M & Zacharek, M 2018, 'International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis', International Forum of Allergy and Rhinology, vol. 8, no. 2, pp. 108-352. https://doi.org/10.1002/alr.22073
Wise, Sarah K. ; Lin, Sandra Y. ; Toskala, Elina ; Orlandi, Richard R. ; Akdis, Cezmi A. ; Alt, Jeremiah A. ; Azar, Antoine ; Baroody, Fuad M. ; Bachert, Claus ; Canonica, G. Walter ; Chacko, Thomas ; Cingi, Cemal ; Ciprandi, Giorgio ; Corey, Jacquelynne ; Cox, Linda S. ; Creticos, Peter Socrates ; Custovic, Adnan ; Damask, Cecelia ; DeConde, Adam ; DelGaudio, John M. ; Ebert, Charles S. ; Eloy, Jean Anderson ; Flanagan, Carrie E. ; Fokkens, Wytske J. ; Franzese, Christine ; Gosepath, Jan ; Halderman, Ashleigh ; Hamilton, Robert G. ; Hoffman, Hans Jürgen ; Hohlfeld, Jens M. ; Houser, Steven M. ; Hwang, Peter H. ; Incorvaia, Cristoforo ; Jarvis, Deborah ; Khalid, Ayesha N. ; Kilpeläinen, Maritta ; Kingdom, Todd T. ; Krouse, Helene ; Larenas-Linnemann, Desiree ; Laury, Adrienne M. ; Lee, Stella E. ; Levy, Joshua M. ; Luong, Amber U. ; Marple, Bradley F. ; McCoul, Edward D. ; McMains, K. Christopher ; Melén, Erik ; Mims, James W. ; Moscato, Gianna ; Mullol, Joaquim ; Nelson, Harold S. ; Patadia, Monica ; Pawankar, Ruby ; Pfaar, Oliver ; Platt, Michael P. ; Reisacher, William ; Rondón, Carmen ; Rudmik, Luke ; Ryan, Matthew ; Sastre, Joaquin ; Schlosser, Rodney J. ; Settipane, Russell A. ; Sharma, Hemant P. ; Sheikh, Aziz ; Smith, Timothy L. ; Tantilipikorn, Pongsakorn ; Tversky, Jody R. ; Veling, Maria C. ; Wang, De Yun ; Westman, Marit ; Wickman, Magnus ; Zacharek, Mark. / International Consensus Statement on Allergy and Rhinology : Allergic Rhinitis. In: International Forum of Allergy and Rhinology. 2018 ; Vol. 8, No. 2. pp. 108-352.
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title = "International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis",
abstract = "Background: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). Methods: Using previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus. Results: The ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR. Conclusion: This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.",
keywords = "allergen extract, allergen immunotherapy, allergic rhinitis, allergy, antihistamine, asthma, atopic dermatitis, avoidance, biologic, cockroach, conjunctivitis, consensus, corticosteroid, cough, cromolyn, decongestant, environment, eosinophilic esophagitis, epicutaneous immunotherapy, epidemiology, evidence-based medicine, food allergy, genetics, house dust mite, IgE, immunoglobulin E, immunotherapy, inhalant allergy, leukotriene, microbiome, occupational rhinitis, omalizumab, pathophysiology, perennial, pet dander, pollen, probiotic, quality of life, rhinitis, rhinitis, rhinosinusitis, risk factor, saline, seasonal, sensitization, sinusitis, sleep, socioeconomic, specific IgE, subcutaneous immunotherapy, sublingual immunotherapy, systematic review, total IgE, transcutaneous immunotherapy, validated survey",
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TY - JOUR

T1 - International Consensus Statement on Allergy and Rhinology

T2 - Allergic Rhinitis

AU - Wise, Sarah K.

AU - Lin, Sandra Y.

AU - Toskala, Elina

AU - Orlandi, Richard R.

AU - Akdis, Cezmi A.

AU - Alt, Jeremiah A.

AU - Azar, Antoine

AU - Baroody, Fuad M.

AU - Bachert, Claus

AU - Canonica, G. Walter

AU - Chacko, Thomas

AU - Cingi, Cemal

AU - Ciprandi, Giorgio

AU - Corey, Jacquelynne

AU - Cox, Linda S.

AU - Creticos, Peter Socrates

AU - Custovic, Adnan

AU - Damask, Cecelia

AU - DeConde, Adam

AU - DelGaudio, John M.

AU - Ebert, Charles S.

AU - Eloy, Jean Anderson

AU - Flanagan, Carrie E.

AU - Fokkens, Wytske J.

AU - Franzese, Christine

AU - Gosepath, Jan

AU - Halderman, Ashleigh

AU - Hamilton, Robert G.

AU - Hoffman, Hans Jürgen

AU - Hohlfeld, Jens M.

AU - Houser, Steven M.

AU - Hwang, Peter H.

AU - Incorvaia, Cristoforo

AU - Jarvis, Deborah

AU - Khalid, Ayesha N.

AU - Kilpeläinen, Maritta

AU - Kingdom, Todd T.

AU - Krouse, Helene

AU - Larenas-Linnemann, Desiree

AU - Laury, Adrienne M.

AU - Lee, Stella E.

AU - Levy, Joshua M.

AU - Luong, Amber U.

AU - Marple, Bradley F.

AU - McCoul, Edward D.

AU - McMains, K. Christopher

AU - Melén, Erik

AU - Mims, James W.

AU - Moscato, Gianna

AU - Mullol, Joaquim

AU - Nelson, Harold S.

AU - Patadia, Monica

AU - Pawankar, Ruby

AU - Pfaar, Oliver

AU - Platt, Michael P.

AU - Reisacher, William

AU - Rondón, Carmen

AU - Rudmik, Luke

AU - Ryan, Matthew

AU - Sastre, Joaquin

AU - Schlosser, Rodney J.

AU - Settipane, Russell A.

AU - Sharma, Hemant P.

AU - Sheikh, Aziz

AU - Smith, Timothy L.

AU - Tantilipikorn, Pongsakorn

AU - Tversky, Jody R.

AU - Veling, Maria C.

AU - Wang, De Yun

AU - Westman, Marit

AU - Wickman, Magnus

AU - Zacharek, Mark

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). Methods: Using previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus. Results: The ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR. Conclusion: This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.

AB - Background: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). Methods: Using previously described methodology, specific topics were developed relating to AR. Each topic was assigned a literature review, evidence-based review (EBR), or evidence-based review with recommendations (EBRR) format as dictated by available evidence and purpose within the ICAR:AR document. Following iterative reviews of each topic, the ICAR:AR document was synthesized and reviewed by all authors for consensus. Results: The ICAR:AR document addresses over 100 individual topics related to AR, including diagnosis, pathophysiology, epidemiology, disease burden, risk factors for the development of AR, allergy testing modalities, treatment, and other conditions/comorbidities associated with AR. Conclusion: This critical review of the AR literature has identified several strengths; providers can be confident that treatment decisions are supported by rigorous studies. However, there are also substantial gaps in the AR literature. These knowledge gaps should be viewed as opportunities for improvement, as often the things that we teach and the medicine that we practice are not based on the best quality evidence. This document aims to highlight the strengths and weaknesses of the AR literature to identify areas for future AR research and improved understanding.

KW - allergen extract

KW - allergen immunotherapy

KW - allergic rhinitis

KW - allergy

KW - antihistamine

KW - asthma

KW - atopic dermatitis

KW - avoidance

KW - biologic

KW - cockroach

KW - conjunctivitis

KW - consensus

KW - corticosteroid

KW - cough

KW - cromolyn

KW - decongestant

KW - environment

KW - eosinophilic esophagitis

KW - epicutaneous immunotherapy

KW - epidemiology

KW - evidence-based medicine

KW - food allergy

KW - genetics

KW - house dust mite

KW - IgE

KW - immunoglobulin E

KW - immunotherapy

KW - inhalant allergy

KW - leukotriene

KW - microbiome

KW - occupational rhinitis

KW - omalizumab

KW - pathophysiology

KW - perennial

KW - pet dander

KW - pollen

KW - probiotic

KW - quality of life

KW - rhinitis

KW - rhinitis

KW - rhinosinusitis

KW - risk factor

KW - saline

KW - seasonal

KW - sensitization

KW - sinusitis

KW - sleep

KW - socioeconomic

KW - specific IgE

KW - subcutaneous immunotherapy

KW - sublingual immunotherapy

KW - systematic review

KW - total IgE

KW - transcutaneous immunotherapy

KW - validated survey

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U2 - 10.1002/alr.22073

DO - 10.1002/alr.22073

M3 - Article

VL - 8

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EP - 352

JO - International Forum of Allergy and Rhinology

JF - International Forum of Allergy and Rhinology

SN - 2042-6976

IS - 2

ER -