Abstract
We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes. Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1222-1228 |
| Number of pages | 7 |
| Journal | Pancreas |
| Volume | 47 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 1 2018 |
Fingerprint
Keywords
- Children
- pancreatitis
- registry
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Hepatology
- Endocrinology
Cite this
International study group of pediatric pancreatitis : In search for a Cu RE cohort study: Design and rationale for INSPPIRE 2 from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer. / Uc, Aliye; Perito, Emily R.; Pohl, John F.; Shah, Uzma; Abu-El-Haija, Maisam; Barth, Bradley A; Bellin, Melena D.; Ellery, Kate M.; Fishman, Douglas S.; Gariepy, Cheryl E.; Giefer, Matthew J.; Gonska, Tanja; Heyman, Melvin B.; Himes, Ryan W.; Husain, Sohail Z.; Maqbool, Asim; Mascarenhas, Maria R.; McFerron, Brian A.; Morinville, Veronique D.; Lin, Tom K.; Liu, Quin Y.; Nathan, Jaimie D.; Rhee, Sue J.; Ooi, Chee Y.; Sellers, Zachary M.; Schwarzenberg, Sarah Jane; Serrano, Jose; Troendle, David M; Werlin, Steven L.; Wilschanski, Michael; Zheng, Yuhua; Yuan, Ying; Lowe, Mark E.
In: Pancreas, Vol. 47, No. 10, 01.11.2018, p. 1222-1228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - International study group of pediatric pancreatitis
T2 - In search for a Cu RE cohort study: Design and rationale for INSPPIRE 2 from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer
AU - Uc, Aliye
AU - Perito, Emily R.
AU - Pohl, John F.
AU - Shah, Uzma
AU - Abu-El-Haija, Maisam
AU - Barth, Bradley A
AU - Bellin, Melena D.
AU - Ellery, Kate M.
AU - Fishman, Douglas S.
AU - Gariepy, Cheryl E.
AU - Giefer, Matthew J.
AU - Gonska, Tanja
AU - Heyman, Melvin B.
AU - Himes, Ryan W.
AU - Husain, Sohail Z.
AU - Maqbool, Asim
AU - Mascarenhas, Maria R.
AU - McFerron, Brian A.
AU - Morinville, Veronique D.
AU - Lin, Tom K.
AU - Liu, Quin Y.
AU - Nathan, Jaimie D.
AU - Rhee, Sue J.
AU - Ooi, Chee Y.
AU - Sellers, Zachary M.
AU - Schwarzenberg, Sarah Jane
AU - Serrano, Jose
AU - Troendle, David M
AU - Werlin, Steven L.
AU - Wilschanski, Michael
AU - Zheng, Yuhua
AU - Yuan, Ying
AU - Lowe, Mark E.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes. Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.
AB - We created the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE 2) cohort to study the risk factors, natural history, and outcomes of pediatric acute recurrent pancreatitis and chronic pancreatitis (CP). Patient and physician questionnaires collect information on demographics, clinical history, family and social history, and disease outcomes. Health-related quality of life, depression, and anxiety are measured using validated questionnaires. Information entered on paper questionnaires is transferred into a database managed by Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer's Coordinating and Data Management Center. Biosamples are collected for DNA isolation and analysis of most common pancreatitis-associated genes. Twenty-two sites (18 in the United States, 2 in Canada, and 1 each in Israel and Australia) are participating in the INSPPIRE 2 study. These sites have enrolled 211 subjects into the INSPPIRE 2 database toward our goal to recruit more than 800 patients in 2 years. The INSPPIRE 2 cohort study is an extension of the INSPPIRE cohort study with a larger and more diverse patient population. Our goals have expanded to include evaluating risk factors for CP, its sequelae, and psychosocial factors associated with pediatric acute recurrent pancreatitis and CP.
KW - Children
KW - pancreatitis
KW - registry
UR - http://www.scopus.com/inward/record.url?scp=85055076510&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055076510&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000001172
DO - 10.1097/MPA.0000000000001172
M3 - Article
C2 - 30325861
AN - SCOPUS:85055076510
VL - 47
SP - 1222
EP - 1228
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 10
ER -