International union of pharmacology. LXII. The NR1H and NR1I receptors: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor

David D. Moore, Shigeaki Kato, Wen Xie, David J. Mangelsdorf, Daniel R. Schmidt, Rui Xiao, Steven A. Kliewer

Research output: Contribution to journalReview article

142 Scopus citations

Abstract

The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.

Original languageEnglish (US)
Pages (from-to)742-759
Number of pages18
JournalPharmacological reviews
Volume58
Issue number4
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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