TY - JOUR
T1 - International union of pharmacology. LXII. The NR1H and NR1I receptors
T2 - Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor
AU - Moore, David D.
AU - Kato, Shigeaki
AU - Xie, Wen
AU - Mangelsdorf, David J.
AU - Schmidt, Daniel R.
AU - Xiao, Rui
AU - Kliewer, Steven A.
PY - 2006/12
Y1 - 2006/12
N2 - The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.
AB - The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.
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U2 - 10.1124/pr.58.4.6
DO - 10.1124/pr.58.4.6
M3 - Review article
C2 - 17132852
AN - SCOPUS:33751516329
SN - 0031-6997
VL - 58
SP - 742
EP - 759
JO - Pharmacological reviews
JF - Pharmacological reviews
IS - 4
ER -