International union of pharmacology. LXII. The NR1H and NR1I receptors: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor

David D. Moore, Shigeaki Kato, Wen Xie, David J. Mangelsdorf, Daniel R. Schmidt, Rui Xiao, Steven A. Kliewer

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133 Citations (Scopus)

Abstract

The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.

Original languageEnglish (US)
Pages (from-to)742-759
Number of pages18
JournalPharmacological Reviews
Volume58
Issue number4
DOIs
StatePublished - Dec 2006

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Pregnenes
Calcitriol Receptors
Xenobiotics
Cytoplasmic and Nuclear Receptors
Metabolic Networks and Pathways
Bile Acids and Salts
Cholesterol
Pharmacology
Calcium
constitutive androstane receptor
Liver X Receptors
pregnane X receptor

ASJC Scopus subject areas

  • Pharmacology

Cite this

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title = "International union of pharmacology. LXII. The NR1H and NR1I receptors: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor α, farnesoid X receptor β, liver X receptor α, liver X receptor β, and vitamin D receptor",
abstract = "The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors.",
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AU - Kato, Shigeaki

AU - Xie, Wen

AU - Mangelsdorf, David J.

AU - Schmidt, Daniel R.

AU - Xiao, Rui

AU - Kliewer, Steven A.

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