Interplay of tumor vascular oxygenation and pO
            2 in tumors using NIRS and needle electrode

Gwan Kim Jae Gwan Kim; Y. Song; D. Zhao; A. Constantinescu; R. P. Mason; H. Liu

doi:10.1117/12.434524

Interplay of tumor vascular oxygenation and pO ₂ in tumors using NIRS and needle electrode

Gwan Kim Jae Gwan Kim, Y. Song, D. Zhao, A. Constantinescu, R. P. Mason, H. Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near-infrared spectroscopy system and pO ₂ needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb] _total), oxygenated hemoglobin concentration ([HBO ₂]) and local oxygen tension (pO ₂) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO ₂). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO ₂]/[HbO ₂] _max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO ₂]/[HbO ₂] _max vs. pO ₂ in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.

Original language	English (US)
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Editors	B. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraka
Pages	429-436
Number of pages	8
Volume	4250
DOIs	https://doi.org/10.1117/12.434524
State	Published - 2001
Event	Optical Tomography and Spectroscopy of Tissue IV - San Jose, CA, United States Duration: Jan 21 2001 → Jan 23 2001

Other

Other	Optical Tomography and Spectroscopy of Tissue IV
Country/Territory	United States
City	San Jose, CA
Period	1/21/01 → 1/23/01

Keywords

Frequency-domain spectroscopy
NIR spectroscopy
pO electrode
Tumor vascular oxygenation

ASJC Scopus subject areas

Electrical and Electronic Engineering
Condensed Matter Physics

Access to Document

10.1117/12.434524

Cite this

Jae Gwan Kim, G. K., Song, Y., Zhao, D., Constantinescu, A., Mason, R. P., & Liu, H. (2001). Interplay of tumor vascular oxygenation and pO ₂ in tumors using NIRS and needle electrode In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraka (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4250, pp. 429-436) https://doi.org/10.1117/12.434524

Interplay of tumor vascular oxygenation and pO ₂ in tumors using NIRS and needle electrode . / Jae Gwan Kim, Gwan Kim; Song, Y.; Zhao, D. et al.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraka. Vol. 4250 2001. p. 429-436.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Jae Gwan Kim, GK, Song, Y, Zhao, D, Constantinescu, A, Mason, RP & Liu, H 2001, Interplay of tumor vascular oxygenation and pO ₂ in tumors using NIRS and needle electrode in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraka (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4250, pp. 429-436, Optical Tomography and Spectroscopy of Tissue IV, San Jose, CA, United States, 1/21/01. https://doi.org/10.1117/12.434524

Jae Gwan Kim GK, Song Y, Zhao D, Constantinescu A, Mason RP, Liu H. Interplay of tumor vascular oxygenation and pO ₂ in tumors using NIRS and needle electrode In Chance B, Alfano RR, Tromberg BJ, Tamura M, Sevick-Muraka EM, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4250. 2001. p. 429-436 doi: 10.1117/12.434524

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abstract = "The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near-infrared spectroscopy system and pO 2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb] total), oxygenated hemoglobin concentration ([HBO 2]) and local oxygen tension (pO 2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO 2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO 2]/[HbO 2] max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO 2]/[HbO 2] max vs. pO 2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques. ",

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AB - The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near-infrared spectroscopy system and pO 2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb] total), oxygenated hemoglobin concentration ([HBO 2]) and local oxygen tension (pO 2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO 2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO 2]/[HbO 2] max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO 2]/[HbO 2] max vs. pO 2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.

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