Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode

Gwan Kim Jae Gwan Kim, Y. Song, D. Zhao, A. Constantinescu, R. P. Mason, H. Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near-infrared spectroscopy system and pO 2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb] total), oxygenated hemoglobin concentration ([HBO 2]) and local oxygen tension (pO 2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO 2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO 2]/[HbO 2] max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO 2]/[HbO 2] max vs. pO 2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsB. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraka
Pages429-436
Number of pages8
Volume4250
DOIs
StatePublished - 2001
EventOptical Tomography and Spectroscopy of Tissue IV - San Jose, CA, United States
Duration: Jan 21 2001Jan 23 2001

Other

OtherOptical Tomography and Spectroscopy of Tissue IV
CountryUnited States
CitySan Jose, CA
Period1/21/011/23/01

Fingerprint

Oxygenation
oxygenation
needles
Needles
Tumors
tumors
Electrodes
electrodes
Hemoglobin
hemoglobin
blood
Blood
oxygen tension
physiology
Oxygen
Near infrared spectroscopy
Physiology
rats
Rats
beds

Keywords

  • Frequency-domain spectroscopy
  • NIR spectroscopy
  • pO electrode
  • Tumor vascular oxygenation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Jae Gwan Kim, G. K., Song, Y., Zhao, D., Constantinescu, A., Mason, R. P., & Liu, H. (2001). Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode In B. Chance, R. R. Alfano, B. J. Tromberg, M. Tamura, & E. M. Sevick-Muraka (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4250, pp. 429-436) https://doi.org/10.1117/12.434524

Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode . / Jae Gwan Kim, Gwan Kim; Song, Y.; Zhao, D.; Constantinescu, A.; Mason, R. P.; Liu, H.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / B. Chance; R.R. Alfano; B.J. Tromberg; M. Tamura; E.M. Sevick-Muraka. Vol. 4250 2001. p. 429-436.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Jae Gwan Kim, GK, Song, Y, Zhao, D, Constantinescu, A, Mason, RP & Liu, H 2001, Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode in B Chance, RR Alfano, BJ Tromberg, M Tamura & EM Sevick-Muraka (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4250, pp. 429-436, Optical Tomography and Spectroscopy of Tissue IV, San Jose, CA, United States, 1/21/01. https://doi.org/10.1117/12.434524
Jae Gwan Kim GK, Song Y, Zhao D, Constantinescu A, Mason RP, Liu H. Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode In Chance B, Alfano RR, Tromberg BJ, Tamura M, Sevick-Muraka EM, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4250. 2001. p. 429-436 https://doi.org/10.1117/12.434524
Jae Gwan Kim, Gwan Kim ; Song, Y. ; Zhao, D. ; Constantinescu, A. ; Mason, R. P. ; Liu, H. / Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode Proceedings of SPIE - The International Society for Optical Engineering. editor / B. Chance ; R.R. Alfano ; B.J. Tromberg ; M. Tamura ; E.M. Sevick-Muraka. Vol. 4250 2001. pp. 429-436
@inproceedings{9228cafa27c74d4d9819baedee7b5b2c,
title = "Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode",
abstract = "The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near-infrared spectroscopy system and pO 2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb] total), oxygenated hemoglobin concentration ([HBO 2]) and local oxygen tension (pO 2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95{\%} oxygen, 5{\%} CO 2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO 2]/[HbO 2] max. For comparison, a phantom study was undertaken with 1{\%} intralipid solution and blood. The slope of [HbO 2]/[HbO 2] max vs. pO 2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.",
keywords = "Frequency-domain spectroscopy, NIR spectroscopy, pO electrode, Tumor vascular oxygenation",
author = "{Jae Gwan Kim}, {Gwan Kim} and Y. Song and D. Zhao and A. Constantinescu and Mason, {R. P.} and H. Liu",
year = "2001",
doi = "10.1117/12.434524",
language = "English (US)",
volume = "4250",
pages = "429--436",
editor = "B. Chance and R.R. Alfano and B.J. Tromberg and M. Tamura and E.M. Sevick-Muraka",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Interplay of tumor vascular oxygenation and pO 2 in tumors using NIRS and needle electrode

AU - Jae Gwan Kim, Gwan Kim

AU - Song, Y.

AU - Zhao, D.

AU - Constantinescu, A.

AU - Mason, R. P.

AU - Liu, H.

PY - 2001

Y1 - 2001

N2 - The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near-infrared spectroscopy system and pO 2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb] total), oxygenated hemoglobin concentration ([HBO 2]) and local oxygen tension (pO 2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO 2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO 2]/[HbO 2] max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO 2]/[HbO 2] max vs. pO 2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.

AB - The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near-infrared spectroscopy system and pO 2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb] total), oxygenated hemoglobin concentration ([HBO 2]) and local oxygen tension (pO 2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO 2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO 2]/[HbO 2] max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO 2]/[HbO 2] max vs. pO 2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.

KW - Frequency-domain spectroscopy

KW - NIR spectroscopy

KW - pO electrode

KW - Tumor vascular oxygenation

UR - http://www.scopus.com/inward/record.url?scp=0034859417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034859417&partnerID=8YFLogxK

U2 - 10.1117/12.434524

DO - 10.1117/12.434524

M3 - Conference contribution

AN - SCOPUS:0034859417

VL - 4250

SP - 429

EP - 436

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Chance, B.

A2 - Alfano, R.R.

A2 - Tromberg, B.J.

A2 - Tamura, M.

A2 - Sevick-Muraka, E.M.

ER -