Interreader agreement and variability of FDG PET volumetric parameters in human solid tumors

Vasavi Paidpally, Gustavo Mercier, Bhartesh A. Shah, Srinivasan Senthamizhchelvan, Rathan M. Subramaniam

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of this article is to evaluate the interreader agreement and variability of two 18F-FDG PET parameters, metabolic tumor volume and total lesion glycolysis, in human solid tumors. MATERIALS AND METHODS. One hundred eleven patients (mean [± SD] age, 61.9 ± 12.5 years) with baseline staging FDG PET/CT scans were included. Two readers independently read the scans and segmented metabolic tumor volume and total lesion glycolysis using two fixed thresholds, 40% and 50% of the lesion's maximum standardized uptake value (SUVmax). The impact of the lesion's FDG avidity and location on reader agreement and variability was established. Intraclass correlation coefficient (ICC), precision, and Bland-Altman analysis were used to evaluate agreement and variability. RESULTS. The ICCs for 40% and 50% SUVmax segmentations of metabolic tumor volume between the readers were 0.987 and 0.995, and the corresponding values for 40% and 50% SUVmax segmentations of total lesion glycolysis were 0.987 and 0.986, respectively (p = 0.0001). The corresponding precisions were 0.5%, 0.2%, 0.5%, and 0.5%, respectively. The mean biases between the readers for 40% and 50% SUVmax segmentations of metabolic tumor volume were -1.78 ± 8.42 mL and -0.46 ± 2.1 mL and for 40% and 50% SUV max segmentations of total lesion glycolysis were -7.3 ± 31.6 g and -2.97 ± 12.86 g, respectively. Subgroup analysis showed better precision and lesser variability for 50% SUVmax segmentations of metabolic tumor volume and total lesion glycolysis in patients with the highest and lowest FDGavid primary tumors. The precision was highest and variability was lowest for lung tumors. CONCLUSION. There is excellent interreader agreement for measurement of metabolic tumor volume and total lesion glycolysis with 40% and 50% SUVmax threshold segmentations in human solid tumors.

Original languageEnglish (US)
Pages (from-to)406-412
Number of pages7
JournalAmerican Journal of Roentgenology
Volume202
Issue number2
DOIs
StatePublished - Feb 1 2014

Fingerprint

Glycolysis
Tumor Burden
Neoplasms
Fluorodeoxyglucose F18
Lung

Keywords

  • FDG PET/CT
  • Metabolic tumor volume
  • Total lesion glycolysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Interreader agreement and variability of FDG PET volumetric parameters in human solid tumors. / Paidpally, Vasavi; Mercier, Gustavo; Shah, Bhartesh A.; Senthamizhchelvan, Srinivasan; Subramaniam, Rathan M.

In: American Journal of Roentgenology, Vol. 202, No. 2, 01.02.2014, p. 406-412.

Research output: Contribution to journalArticle

Paidpally, Vasavi ; Mercier, Gustavo ; Shah, Bhartesh A. ; Senthamizhchelvan, Srinivasan ; Subramaniam, Rathan M. / Interreader agreement and variability of FDG PET volumetric parameters in human solid tumors. In: American Journal of Roentgenology. 2014 ; Vol. 202, No. 2. pp. 406-412.
@article{4ff93df7652048fbae66a8bc189fe2da,
title = "Interreader agreement and variability of FDG PET volumetric parameters in human solid tumors",
abstract = "OBJECTIVE. The purpose of this article is to evaluate the interreader agreement and variability of two 18F-FDG PET parameters, metabolic tumor volume and total lesion glycolysis, in human solid tumors. MATERIALS AND METHODS. One hundred eleven patients (mean [± SD] age, 61.9 ± 12.5 years) with baseline staging FDG PET/CT scans were included. Two readers independently read the scans and segmented metabolic tumor volume and total lesion glycolysis using two fixed thresholds, 40{\%} and 50{\%} of the lesion's maximum standardized uptake value (SUVmax). The impact of the lesion's FDG avidity and location on reader agreement and variability was established. Intraclass correlation coefficient (ICC), precision, and Bland-Altman analysis were used to evaluate agreement and variability. RESULTS. The ICCs for 40{\%} and 50{\%} SUVmax segmentations of metabolic tumor volume between the readers were 0.987 and 0.995, and the corresponding values for 40{\%} and 50{\%} SUVmax segmentations of total lesion glycolysis were 0.987 and 0.986, respectively (p = 0.0001). The corresponding precisions were 0.5{\%}, 0.2{\%}, 0.5{\%}, and 0.5{\%}, respectively. The mean biases between the readers for 40{\%} and 50{\%} SUVmax segmentations of metabolic tumor volume were -1.78 ± 8.42 mL and -0.46 ± 2.1 mL and for 40{\%} and 50{\%} SUV max segmentations of total lesion glycolysis were -7.3 ± 31.6 g and -2.97 ± 12.86 g, respectively. Subgroup analysis showed better precision and lesser variability for 50{\%} SUVmax segmentations of metabolic tumor volume and total lesion glycolysis in patients with the highest and lowest FDGavid primary tumors. The precision was highest and variability was lowest for lung tumors. CONCLUSION. There is excellent interreader agreement for measurement of metabolic tumor volume and total lesion glycolysis with 40{\%} and 50{\%} SUVmax threshold segmentations in human solid tumors.",
keywords = "FDG PET/CT, Metabolic tumor volume, Total lesion glycolysis",
author = "Vasavi Paidpally and Gustavo Mercier and Shah, {Bhartesh A.} and Srinivasan Senthamizhchelvan and Subramaniam, {Rathan M.}",
year = "2014",
month = "2",
day = "1",
doi = "10.2214/AJR.13.10841",
language = "English (US)",
volume = "202",
pages = "406--412",
journal = "American Journal of Roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
number = "2",

}

TY - JOUR

T1 - Interreader agreement and variability of FDG PET volumetric parameters in human solid tumors

AU - Paidpally, Vasavi

AU - Mercier, Gustavo

AU - Shah, Bhartesh A.

AU - Senthamizhchelvan, Srinivasan

AU - Subramaniam, Rathan M.

PY - 2014/2/1

Y1 - 2014/2/1

N2 - OBJECTIVE. The purpose of this article is to evaluate the interreader agreement and variability of two 18F-FDG PET parameters, metabolic tumor volume and total lesion glycolysis, in human solid tumors. MATERIALS AND METHODS. One hundred eleven patients (mean [± SD] age, 61.9 ± 12.5 years) with baseline staging FDG PET/CT scans were included. Two readers independently read the scans and segmented metabolic tumor volume and total lesion glycolysis using two fixed thresholds, 40% and 50% of the lesion's maximum standardized uptake value (SUVmax). The impact of the lesion's FDG avidity and location on reader agreement and variability was established. Intraclass correlation coefficient (ICC), precision, and Bland-Altman analysis were used to evaluate agreement and variability. RESULTS. The ICCs for 40% and 50% SUVmax segmentations of metabolic tumor volume between the readers were 0.987 and 0.995, and the corresponding values for 40% and 50% SUVmax segmentations of total lesion glycolysis were 0.987 and 0.986, respectively (p = 0.0001). The corresponding precisions were 0.5%, 0.2%, 0.5%, and 0.5%, respectively. The mean biases between the readers for 40% and 50% SUVmax segmentations of metabolic tumor volume were -1.78 ± 8.42 mL and -0.46 ± 2.1 mL and for 40% and 50% SUV max segmentations of total lesion glycolysis were -7.3 ± 31.6 g and -2.97 ± 12.86 g, respectively. Subgroup analysis showed better precision and lesser variability for 50% SUVmax segmentations of metabolic tumor volume and total lesion glycolysis in patients with the highest and lowest FDGavid primary tumors. The precision was highest and variability was lowest for lung tumors. CONCLUSION. There is excellent interreader agreement for measurement of metabolic tumor volume and total lesion glycolysis with 40% and 50% SUVmax threshold segmentations in human solid tumors.

AB - OBJECTIVE. The purpose of this article is to evaluate the interreader agreement and variability of two 18F-FDG PET parameters, metabolic tumor volume and total lesion glycolysis, in human solid tumors. MATERIALS AND METHODS. One hundred eleven patients (mean [± SD] age, 61.9 ± 12.5 years) with baseline staging FDG PET/CT scans were included. Two readers independently read the scans and segmented metabolic tumor volume and total lesion glycolysis using two fixed thresholds, 40% and 50% of the lesion's maximum standardized uptake value (SUVmax). The impact of the lesion's FDG avidity and location on reader agreement and variability was established. Intraclass correlation coefficient (ICC), precision, and Bland-Altman analysis were used to evaluate agreement and variability. RESULTS. The ICCs for 40% and 50% SUVmax segmentations of metabolic tumor volume between the readers were 0.987 and 0.995, and the corresponding values for 40% and 50% SUVmax segmentations of total lesion glycolysis were 0.987 and 0.986, respectively (p = 0.0001). The corresponding precisions were 0.5%, 0.2%, 0.5%, and 0.5%, respectively. The mean biases between the readers for 40% and 50% SUVmax segmentations of metabolic tumor volume were -1.78 ± 8.42 mL and -0.46 ± 2.1 mL and for 40% and 50% SUV max segmentations of total lesion glycolysis were -7.3 ± 31.6 g and -2.97 ± 12.86 g, respectively. Subgroup analysis showed better precision and lesser variability for 50% SUVmax segmentations of metabolic tumor volume and total lesion glycolysis in patients with the highest and lowest FDGavid primary tumors. The precision was highest and variability was lowest for lung tumors. CONCLUSION. There is excellent interreader agreement for measurement of metabolic tumor volume and total lesion glycolysis with 40% and 50% SUVmax threshold segmentations in human solid tumors.

KW - FDG PET/CT

KW - Metabolic tumor volume

KW - Total lesion glycolysis

UR - http://www.scopus.com/inward/record.url?scp=84892733239&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892733239&partnerID=8YFLogxK

U2 - 10.2214/AJR.13.10841

DO - 10.2214/AJR.13.10841

M3 - Article

C2 - 24450684

AN - SCOPUS:84892733239

VL - 202

SP - 406

EP - 412

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

SN - 0361-803X

IS - 2

ER -