Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts

Jun Wu, Juan Carlos Izpisua Belmonte

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

The past decade’s rapid progress in human pluripotent stem cell (hPSC) research has generated hope for meeting the rising demand of organ donation, which remains the only effective cure for end-stage organ failure, a major cause of death worldwide. Despite the potential, generation of transplantable organs from hPSCs using in vitro differentiation is far-fetched. An in vivo interspecies chimeric complementation strategy relying on chimeric-competent hPSCs and zygote genome editing provides an auspicious alternative for providing unlimited organ source for transplantation.

Original languageEnglish (US)
Pages (from-to)375-384
Number of pages10
JournalTransgenic Research
Volume25
Issue number3
DOIs
Publication statusPublished - Jun 1 2016
Externally publishedYes

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Keywords

  • Blastocyst complementation
  • In vivo genome editing
  • Interspecies chimera
  • iPSCs
  • Organ transplantation
  • Pluripotent stem cells

ASJC Scopus subject areas

  • Biotechnology
  • Animal Science and Zoology
  • Genetics
  • Agronomy and Crop Science

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