Interspecific Complementation between Mouse and Chinese Hamster Cell Mutants Hypersensitive to Ionizing Radiation

K. Sato, D. J. Chen, K. Eguchi-Kasai, H. Itsukaichi, T. Odaka, G. F. Strniste

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Ionizing radiation-sensitive mutant/Complementation test/Interspecific hybrid/Mouse cell/Hamster cell Interspecific and intraspecific hybrids were formed between mouse and Chinese hamster cell mutants hypersensitive to ionizing radiation and their radiosensitivities were examined. Chinese hamster cell mutants irsl, irs2 and irs3 and mouse mammary carcinoma cell mutants SX9 and SX10 have been found to belong to five different complementation groups. A radiosensitive mouse lymphoma cell line L5178Y-S has been demonstrated to be different from the X-ray sensitive mouse cell mutants M10 and LX830, both of which are derived from L5178Y cells, in their complementation groups. L5178Y-S is also distinct from SX9 and SX10.

Original languageEnglish (US)
Pages (from-to)38-45
Number of pages8
JournalJournal of radiation research
Volume36
Issue number1
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Health, Toxicology and Mutagenesis

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