Interstitial continuous infusion therapy in a malignant glioma model in rats

Yuichi Tange, Akihide Kondo, Merrill J. Egorin, Barbara Mania-Farnell, Georgy M. Daneriallis, Hiromichi Nakazaki, Simone T. Sredni, Veena Rajaram, Stewart Goldman, Marcelo B. Soares, Tadanori Tomita

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Purpose: Local direct delivery of chemotherapeutic agents for the treatment of brain tumors is an area of focus in the development of new therapeutic paradigms. These techniques need improvement, especially in terms of drug retention in brain tissue. Materials and methods: In this study, we used a rat glioma model to examine carboplatin distribution, as measured by platinum penetration, after delivery via interstitial continuous (i.c.) infusion. We also examined rat survival times in response to carboplatin and oxaliplatin. I.C. infusion, a modified version of convection-enhanced delivery (CED) for local drug delivery, uses low volume (1 μl per hour) continuous infusion directly into the tumor. Results: I.C. infusion produced a nearly 360-fold higher concentration of platinum in tumor tissue and significantly prolonged rodent survival time compared to intraperitoneal (i.p.) infusion. Conclusions: We showed i.c. infusion allows for circumvention of the blood-brain barrier, focused drug distribution, and sustained drug delivery. This method could be a promising strategy for treating brain tumors.

Original languageEnglish (US)
Pages (from-to)655-662
Number of pages8
JournalChild's Nervous System
Volume25
Issue number6
DOIs
StatePublished - Jun 1 2009

Keywords

  • Carboplatin
  • Chemotherapy
  • Convection-enhanced delivery
  • Oxaliplatin
  • Rat model

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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  • Cite this

    Tange, Y., Kondo, A., Egorin, M. J., Mania-Farnell, B., Daneriallis, G. M., Nakazaki, H., Sredni, S. T., Rajaram, V., Goldman, S., Soares, M. B., & Tomita, T. (2009). Interstitial continuous infusion therapy in a malignant glioma model in rats. Child's Nervous System, 25(6), 655-662. https://doi.org/10.1007/s00381-008-0805-3