Intestinal absorption of polyenephosphatidylcholine in man

O. Zierenberg, Scott M Grundy

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

The metabolic fate of 1 g of 3H/14C-labeled dilinoleoglycerophosphocholine was studied in five patients after oral administration. The 3H label was in choline and 14C was in the two linoleic acid residues. More than 90% of both isotopes was absorbed from the intestine. Seventy to 90% of the 3H radioactivity in blood was linked to phosphatidylcholine (PC) whereas 14C was associated with both PC and nonpolar lipids. At peak activity, the 3H/14C ratio of plasma PC was twice that of oral PC; this suggests that most oral PC was hydrolyzed to lysolecithin before absorption. The mean maximum concentration in total blood volume was 20% of the administered dose for 3H and 28% for 14C. Examination of lipoproteins revealed that the specific activity of PC in high density lipoprotein (HDL) was 2 to 6 times higher than in apoB-containing lipoproteins, and 2 to 20 times than that of red blood cells or total blood. Thus, absorbed PC seemingly was incorporated preferentially into the HDL fraction of plasma.

Original languageEnglish (US)
Pages (from-to)1136-1142
Number of pages7
JournalJournal of Lipid Research
Volume23
Issue number8
StatePublished - 1982

Fingerprint

Intestinal Absorption
Phosphatidylcholines
Blood
HDL Lipoproteins
Lipoproteins
HDL2 Lipoprotein
Plasmas
Lysophosphatidylcholines
Radioactivity
Apolipoproteins B
Linoleic Acid
Choline
Blood Volume
Isotopes
Intestines
Oral Administration
Labels
Erythrocytes
Cells
Lipids

ASJC Scopus subject areas

  • Endocrinology

Cite this

Intestinal absorption of polyenephosphatidylcholine in man. / Zierenberg, O.; Grundy, Scott M.

In: Journal of Lipid Research, Vol. 23, No. 8, 1982, p. 1136-1142.

Research output: Contribution to journalArticle

@article{479fc45c73dd4b4d8aafba34abfb864c,
title = "Intestinal absorption of polyenephosphatidylcholine in man",
abstract = "The metabolic fate of 1 g of 3H/14C-labeled dilinoleoglycerophosphocholine was studied in five patients after oral administration. The 3H label was in choline and 14C was in the two linoleic acid residues. More than 90{\%} of both isotopes was absorbed from the intestine. Seventy to 90{\%} of the 3H radioactivity in blood was linked to phosphatidylcholine (PC) whereas 14C was associated with both PC and nonpolar lipids. At peak activity, the 3H/14C ratio of plasma PC was twice that of oral PC; this suggests that most oral PC was hydrolyzed to lysolecithin before absorption. The mean maximum concentration in total blood volume was 20{\%} of the administered dose for 3H and 28{\%} for 14C. Examination of lipoproteins revealed that the specific activity of PC in high density lipoprotein (HDL) was 2 to 6 times higher than in apoB-containing lipoproteins, and 2 to 20 times than that of red blood cells or total blood. Thus, absorbed PC seemingly was incorporated preferentially into the HDL fraction of plasma.",
author = "O. Zierenberg and Grundy, {Scott M}",
year = "1982",
language = "English (US)",
volume = "23",
pages = "1136--1142",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "8",

}

TY - JOUR

T1 - Intestinal absorption of polyenephosphatidylcholine in man

AU - Zierenberg, O.

AU - Grundy, Scott M

PY - 1982

Y1 - 1982

N2 - The metabolic fate of 1 g of 3H/14C-labeled dilinoleoglycerophosphocholine was studied in five patients after oral administration. The 3H label was in choline and 14C was in the two linoleic acid residues. More than 90% of both isotopes was absorbed from the intestine. Seventy to 90% of the 3H radioactivity in blood was linked to phosphatidylcholine (PC) whereas 14C was associated with both PC and nonpolar lipids. At peak activity, the 3H/14C ratio of plasma PC was twice that of oral PC; this suggests that most oral PC was hydrolyzed to lysolecithin before absorption. The mean maximum concentration in total blood volume was 20% of the administered dose for 3H and 28% for 14C. Examination of lipoproteins revealed that the specific activity of PC in high density lipoprotein (HDL) was 2 to 6 times higher than in apoB-containing lipoproteins, and 2 to 20 times than that of red blood cells or total blood. Thus, absorbed PC seemingly was incorporated preferentially into the HDL fraction of plasma.

AB - The metabolic fate of 1 g of 3H/14C-labeled dilinoleoglycerophosphocholine was studied in five patients after oral administration. The 3H label was in choline and 14C was in the two linoleic acid residues. More than 90% of both isotopes was absorbed from the intestine. Seventy to 90% of the 3H radioactivity in blood was linked to phosphatidylcholine (PC) whereas 14C was associated with both PC and nonpolar lipids. At peak activity, the 3H/14C ratio of plasma PC was twice that of oral PC; this suggests that most oral PC was hydrolyzed to lysolecithin before absorption. The mean maximum concentration in total blood volume was 20% of the administered dose for 3H and 28% for 14C. Examination of lipoproteins revealed that the specific activity of PC in high density lipoprotein (HDL) was 2 to 6 times higher than in apoB-containing lipoproteins, and 2 to 20 times than that of red blood cells or total blood. Thus, absorbed PC seemingly was incorporated preferentially into the HDL fraction of plasma.

UR - http://www.scopus.com/inward/record.url?scp=0020351049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020351049&partnerID=8YFLogxK

M3 - Article

C2 - 7175371

AN - SCOPUS:0020351049

VL - 23

SP - 1136

EP - 1142

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

IS - 8

ER -