Intestinal epithelial Tollerance versus inTollerance of commensals

Elke Cario, Daniel K. Podolsky

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

This brief review summarizes the current understanding of Toll-like receptor (TLRs) mediated intestinal epithelial mechanisms of commensal tolerance versus intolerance and provides an update on the downstream negative control of signaling responses through decreased surface expression, interregulation with NOD2, overexpression of Tollip, various inhibitors of NF-κB as well as soluble tolerizing mediators present in lumen and serum which all may maintain or - when dysregulated - impair mucosal homeostasis in health or disease, respectively.

Original languageEnglish (US)
Pages (from-to)887-893
Number of pages7
JournalMolecular Immunology
Volume42
Issue number8
DOIs
StatePublished - May 2005

Keywords

  • Host-microbe interactions
  • Innate immunity
  • Intestinal epithelium
  • Tolerance
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

Fingerprint Dive into the research topics of 'Intestinal epithelial Tollerance versus inTollerance of commensals'. Together they form a unique fingerprint.

  • Cite this