Abstract
This brief review summarizes the current understanding of Toll-like receptor (TLRs) mediated intestinal epithelial mechanisms of commensal tolerance versus intolerance and provides an update on the downstream negative control of signaling responses through decreased surface expression, interregulation with NOD2, overexpression of Tollip, various inhibitors of NF-κB as well as soluble tolerizing mediators present in lumen and serum which all may maintain or - when dysregulated - impair mucosal homeostasis in health or disease, respectively.
Original language | English (US) |
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Pages (from-to) | 887-893 |
Number of pages | 7 |
Journal | Molecular Immunology |
Volume | 42 |
Issue number | 8 |
DOIs | |
State | Published - May 2005 |
Keywords
- Host-microbe interactions
- Innate immunity
- Intestinal epithelium
- Tolerance
- Toll-like receptor
ASJC Scopus subject areas
- Immunology
- Molecular Biology