Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut

Aiguo Tian, Jin Jiang

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Stem cells are maintained in a specialized microenvironment called niche but the nature of stem cell niche remains poorly defined in many systems. Here we demonstrate that intestinal epithelium-derived BMP serves as a niche signal for intestinal stem cell (ISC) self-renewal in Drosophila adult midgut. We find that BMP signaling is asymmetric between ISC and its differentiated daughter cell. Two BMP ligands, Dpp and Gbb, are produced by enterocytes and act in conjunction to promote ISC self-renewal by antagonizing Notch signaling. Furthermore, the basement membrane-associated type IV collagens regulate ISC self-renewal by confining higher BMP signaling to ISCs. The employment of gut epithelia as a niche for stem cell self-renewal may provide a mechanism for direct communication between the niche and the environment, allowing niche signal production and stem cell number to be fine-tuned in response to various physiological and pathological stimuli.

Original languageEnglish (US)
Article numbere01857
JournaleLife
Volume2014
Issue number3
DOIs
StatePublished - Mar 11 2014

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Intestinal Mucosa
Stem cells
Drosophila
Stem Cells
Stem Cell Niche
Collagen Type IV
Enterocytes
Epithelium
Cell Count
Communication
Ligands
Cell Self Renewal

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Intestinal epithelium-derived BMP controls stem cell self-renewal in Drosophila adult midgut. / Tian, Aiguo; Jiang, Jin.

In: eLife, Vol. 2014, No. 3, e01857, 11.03.2014.

Research output: Contribution to journalArticle

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