Intestinal Hexose Transport

In the discussion of hexose transport by the intestine, Gardner, Brown and Laster¹ emphasize the point that “existing data are compatible with the hypothesis that sugars are transported… by a carrier-mediated process and that the rate and direction of transport… does not defend directly on cellular energy production, but instead on the distribution ratio of sodium”… Using an isolated cell preparation from chicken small intestine² Kimmich has accumulated data that clearly refute this hypothesis. He has shown that cells with a reversed sodium gradient still accumulate sugar.³ In addition, the rate and extent of this accumulation appear.