TY - JOUR
T1 - Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
AU - Thiennimitr, Parameth
AU - Winter, Sebastian E.
AU - Winter, Maria G.
AU - Xavier, Mariana N.
AU - Tolstikov, Vladimir
AU - Huseby, Douglas L.
AU - Sterzenbach, Torsten
AU - Tsolis, Renée M.
AU - Roth, John R.
AU - Bäumler, Andreas J.
PY - 2011/10/18
Y1 - 2011/10/18
N2 - Conventional wisdom holds that microbes support their growth in vertebrate hosts by exploiting a large variety of nutrients. We show here that use of a specific nutrient (ethanolamine) confers a marked growth advantage on Salmonella enterica serovar Typhimurium (S. Typhimurium) in the lumen of the inflamed intestine. In the anaerobic environment of the gut, ethanolamine supports little or no growth by fermentation. However, S. Typhimurium is able to use this carbon source by inducing the gut to produce a respiratory electron acceptor (tetrathionate), which supports anaerobic growth on ethanolamine. The gut normally converts ambient hydrogen sulfide to thiosulfate, which it then oxidizes further to tetrathionate during inflammation. Evidence is provided that S. Typhimurium's growth advantage in an inflamed gut is because of its ability to respire ethanolamine, which is released from host tissue, but is not utilizable by competing bacteria. By inducing intestinal inflammation, S. Typhimurium sidesteps nutritional competition and gains the ability to use an abundant simple substrate, ethanolamine, which is provided by the host.
AB - Conventional wisdom holds that microbes support their growth in vertebrate hosts by exploiting a large variety of nutrients. We show here that use of a specific nutrient (ethanolamine) confers a marked growth advantage on Salmonella enterica serovar Typhimurium (S. Typhimurium) in the lumen of the inflamed intestine. In the anaerobic environment of the gut, ethanolamine supports little or no growth by fermentation. However, S. Typhimurium is able to use this carbon source by inducing the gut to produce a respiratory electron acceptor (tetrathionate), which supports anaerobic growth on ethanolamine. The gut normally converts ambient hydrogen sulfide to thiosulfate, which it then oxidizes further to tetrathionate during inflammation. Evidence is provided that S. Typhimurium's growth advantage in an inflamed gut is because of its ability to respire ethanolamine, which is released from host tissue, but is not utilizable by competing bacteria. By inducing intestinal inflammation, S. Typhimurium sidesteps nutritional competition and gains the ability to use an abundant simple substrate, ethanolamine, which is provided by the host.
KW - Diarrhea
KW - Gastroenteritis
KW - Metabolism
UR - http://www.scopus.com/inward/record.url?scp=80054806900&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054806900&partnerID=8YFLogxK
U2 - 10.1073/pnas.1107857108
DO - 10.1073/pnas.1107857108
M3 - Article
C2 - 21969563
AN - SCOPUS:80054806900
SN - 0027-8424
VL - 108
SP - 17480
EP - 17485
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 42
ER -