Intestinal metaplasia, not atrophy or achlorhydria, creates a hostile environment for helicobacter pylori

R. M. Genta, D. Y. Graham

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A 54-year-old man with dyspepsia, Helicobacter pylori-associated chronic active atrophic gastritis without intestinal metaplasia, and hyperplastic gastric polyps was followed up for 1 year after H. pylori eradication with sequential endoscopic gastric mucosal mapping and gastric function tests. Eradication of H. pylori by triple therapy resulted in the histologic resolution of gastritis. However, the patient's condition, gastric function, and morphology of the polyps were not affected. This case illustrates that: a) in the absence of intestinal metaplasia, H. pylori can infect the stomach with gastric atrophy; b) the absence of acid does not preclude H. pylori infection; c) advanced atrophic gastritis may be an irreversible condition; and (d) the neutrophilic infiltrate in hyperplastic polyps is independent of the presence of H. pylori.

Original languageEnglish (US)
Pages (from-to)924-928
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume28
Issue number10
DOIs
StatePublished - 1993

Fingerprint

Achlorhydria
Metaplasia
Helicobacter pylori
Atrophy
Stomach
Polyps
Atrophic Gastritis
Dyspepsia
Helicobacter Infections
Gastritis
Acids

Keywords

  • Achlorhydria
  • Atrophic gastritis
  • Chronic active gastritis
  • Helicobacter pylori
  • Histopathology
  • Hyperplastic polyps
  • Intestinal metaplasia
  • Stains
  • Triple therapy

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Intestinal metaplasia, not atrophy or achlorhydria, creates a hostile environment for helicobacter pylori. / Genta, R. M.; Graham, D. Y.

In: Scandinavian Journal of Gastroenterology, Vol. 28, No. 10, 1993, p. 924-928.

Research output: Contribution to journalArticle

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