Intestinal metaplasia with adherent Helicobacter pylori: A hybrid epithelium with both gastric and intestinal features

Hiroyoshi Ota, Tsutomu Katsuyama, Shigemi Nakajima, Hala El-Zimaity, Jong G. Kim, David Y. Graham, Robert M. Genta

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Helicobacter pylori seem to avoid areas of intestinal metaplasia in the gastric mucosa, but attachment of these bacteria to epithelium with the appearance of incomplete intestinal metaplasia has been documented. To characterize the nature of the epithelium to which H pylori was attached, we carried out an immunohistochemical study using monoclonal antibodies against gastric surface mucous cell mucins (M1), blood group-related carbohydrates antigens (Lea, sialyl Lea, Leb, type 1H, and type 2H) and sialyl Tn antigen. The results of this study suggest that these areas of H pylori attachment represent a hybrid epithelium whose cells share characteristics of both gastric surface mucous cells and intestinal metaplastic cells. Whether all areas of incomplete intestinal metaplasia represent an intermediate stage between the normal gastric epithelium and the fully developed complete type of metaplasia remains to be determined.

Original languageEnglish (US)
Pages (from-to)846-850
Number of pages5
JournalHuman Pathology
Volume29
Issue number8
DOIs
StatePublished - Jan 1 1998

Keywords

  • Bacterial adherence
  • Dysplasia
  • Gastric cancer
  • Gastritis
  • Helicobacter
  • Helicobacter pylori
  • Metaplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Ota, H., Katsuyama, T., Nakajima, S., El-Zimaity, H., Kim, J. G., Graham, D. Y., & Genta, R. M. (1998). Intestinal metaplasia with adherent Helicobacter pylori: A hybrid epithelium with both gastric and intestinal features. Human Pathology, 29(8), 846-850. https://doi.org/10.1016/S0046-8177(98)90455-5