Intestinal nuclear receptors in HDL cholesterol metabolism

Chiara Degirolamo, Carlo Sabbà, Antonio Moschetta

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The intestine plays a pivotal role in cholesterol homeostasis by functioning as an absorptive and secretory organ in the reverse cholesterol transport pathway. Enterocytes control cholesterol absorption, apoAI synthesis, HDL biogenesis, and nonbiliary cholesterol fecal disposal. Thus, intestine-based therapeutic interventions may hold promise in the management of diseases driven by cholesterol overload. Lipid-sensing nuclear receptors (NRs) are highly expressed in the intestinal epithelium and regulate transcriptionally the handling of cholesterol by the enterocytes. Here, we discuss the NR regulation of cholesterol fluxes across the enterocytes with special emphasis on NR exploitation as a bona fide novel HDL-raising strategy.

Original languageEnglish (US)
Pages (from-to)1262-1270
Number of pages9
JournalJournal of Lipid Research
Volume56
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Atherosclerosis
  • Gene expression
  • High density lipoprotein
  • Lipoprotein
  • Transcription
  • Transport

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

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