Intestinal polyp formation in the Apcmin mouse: Effects of levels of dietary calcium and altered vitamin D homeostasis

Sergio Huerta, Ronald W. Irwin, David Heber, Vay Liang W Go, Farhad Moatamed, Sara Huerta, Che Ou, Diane M. Harris

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

This study evaluated the effects of various levels of dietary calcium on polyp formation, vitamin D homeostasis, and fecal bile acids in the Apcmin mouse. Female Apcmin mice were randomized to three groups and fed a purified diet with either half or double the level of calcium in control AIN-93G. Serum 25-OH-D and fecal bile acids were measured at weeks 0 and 12 of treatment. Mice were killed for polyp scoring by two observers blinded to treatment after 12 weeks. Results show there was no difference in polyp number or tumor load with dietary calcium in any treatment group. Serum 25-OH-D was reduced and total fecal bile acids were increased in animals that received the high calcium diet. We have previously shown that vitamin D supplementation diminishes polyp load; the lack of effect of an altered calcium diet seen here may be due to a disturbance in vitamin D homeostasis.

Original languageEnglish (US)
Pages (from-to)870-876
Number of pages7
JournalDigestive Diseases and Sciences
Volume48
Issue number5
DOIs
StatePublished - May 1 2003

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Keywords

  • Adenomatous polyposis coli
  • Calcium
  • Chemoprevention
  • Colon cancer
  • Vitamin D

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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