Abstract
Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of intestinal stem cell maintenance, proliferation and differentiation is critical for maintaining gut homeostasis. Here we review recent genetic studies of stem cell-mediated homeostatic growth in the . Drosophila midgut and the mouse small intestine, highlighting similarities and differences in the mechanisms that control stem cell proliferation and differentiation.
Original language | English (US) |
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Pages (from-to) | 354-360 |
Number of pages | 7 |
Journal | Current Opinion in Genetics and Development |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2012 |
ASJC Scopus subject areas
- Genetics
- Developmental Biology