Intestinal stem cell response to injury

lessons from Drosophila

Huaqi Jiang, Aiguo Tian, Jin Jiang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Many adult tissues and organs are maintained by resident stem cells that are activated in response to injury but the mechanisms that regulate stem cell activity during regeneration are still poorly understood. An emerging system to study such problem is the Drosophila adult midgut. Recent studies have identified both intrinsic factors and extrinsic niche signals that control the proliferation, self-renewal, and lineage differentiation of Drosophila adult intestinal stem cells (ISCs). These findings set up the stage to interrogate how niche signals are regulated and how they are integrated with cell-intrinsic factors to control ISC activity during normal homeostasis and regeneration. Here we review the current understanding of the mechanisms that control ISC self-renewal, proliferation, and lineage differentiation in Drosophila adult midgut with a focus on the niche signaling network that governs ISC activity in response to injury.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalCellular and Molecular Life Sciences
DOIs
StateAccepted/In press - May 2 2016

Fingerprint

Drosophila
Stem Cells
Intrinsic Factor
Wounds and Injuries
Regeneration
Adult Stem Cells
Homeostasis

Keywords

  • Aging
  • Asymmetric division
  • BMP
  • Calcium
  • Dpp
  • EGFR
  • Gbb
  • Hedgehog
  • Hh
  • Hippo
  • InR
  • Insulin
  • ISC
  • JAK-STAT
  • JNK
  • microRNA
  • midgut
  • N
  • Notch
  • Proliferation
  • Ras
  • Regeneration
  • Self-renewal
  • Symmetric division
  • Tissue damage
  • Tumor
  • Wg
  • Wnt
  • Yap
  • Yki

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Intestinal stem cell response to injury : lessons from Drosophila. / Jiang, Huaqi; Tian, Aiguo; Jiang, Jin.

In: Cellular and Molecular Life Sciences, 02.05.2016, p. 1-13.

Research output: Contribution to journalArticle

@article{89c1440b8dca4b2485572bf11486ba39,
title = "Intestinal stem cell response to injury: lessons from Drosophila",
abstract = "Many adult tissues and organs are maintained by resident stem cells that are activated in response to injury but the mechanisms that regulate stem cell activity during regeneration are still poorly understood. An emerging system to study such problem is the Drosophila adult midgut. Recent studies have identified both intrinsic factors and extrinsic niche signals that control the proliferation, self-renewal, and lineage differentiation of Drosophila adult intestinal stem cells (ISCs). These findings set up the stage to interrogate how niche signals are regulated and how they are integrated with cell-intrinsic factors to control ISC activity during normal homeostasis and regeneration. Here we review the current understanding of the mechanisms that control ISC self-renewal, proliferation, and lineage differentiation in Drosophila adult midgut with a focus on the niche signaling network that governs ISC activity in response to injury.",
keywords = "Aging, Asymmetric division, BMP, Calcium, Dpp, EGFR, Gbb, Hedgehog, Hh, Hippo, InR, Insulin, ISC, JAK-STAT, JNK, microRNA, midgut, N, Notch, Proliferation, Ras, Regeneration, Self-renewal, Symmetric division, Tissue damage, Tumor, Wg, Wnt, Yap, Yki",
author = "Huaqi Jiang and Aiguo Tian and Jin Jiang",
year = "2016",
month = "5",
day = "2",
doi = "10.1007/s00018-016-2235-9",
language = "English (US)",
pages = "1--13",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",

}

TY - JOUR

T1 - Intestinal stem cell response to injury

T2 - lessons from Drosophila

AU - Jiang, Huaqi

AU - Tian, Aiguo

AU - Jiang, Jin

PY - 2016/5/2

Y1 - 2016/5/2

N2 - Many adult tissues and organs are maintained by resident stem cells that are activated in response to injury but the mechanisms that regulate stem cell activity during regeneration are still poorly understood. An emerging system to study such problem is the Drosophila adult midgut. Recent studies have identified both intrinsic factors and extrinsic niche signals that control the proliferation, self-renewal, and lineage differentiation of Drosophila adult intestinal stem cells (ISCs). These findings set up the stage to interrogate how niche signals are regulated and how they are integrated with cell-intrinsic factors to control ISC activity during normal homeostasis and regeneration. Here we review the current understanding of the mechanisms that control ISC self-renewal, proliferation, and lineage differentiation in Drosophila adult midgut with a focus on the niche signaling network that governs ISC activity in response to injury.

AB - Many adult tissues and organs are maintained by resident stem cells that are activated in response to injury but the mechanisms that regulate stem cell activity during regeneration are still poorly understood. An emerging system to study such problem is the Drosophila adult midgut. Recent studies have identified both intrinsic factors and extrinsic niche signals that control the proliferation, self-renewal, and lineage differentiation of Drosophila adult intestinal stem cells (ISCs). These findings set up the stage to interrogate how niche signals are regulated and how they are integrated with cell-intrinsic factors to control ISC activity during normal homeostasis and regeneration. Here we review the current understanding of the mechanisms that control ISC self-renewal, proliferation, and lineage differentiation in Drosophila adult midgut with a focus on the niche signaling network that governs ISC activity in response to injury.

KW - Aging

KW - Asymmetric division

KW - BMP

KW - Calcium

KW - Dpp

KW - EGFR

KW - Gbb

KW - Hedgehog

KW - Hh

KW - Hippo

KW - InR

KW - Insulin

KW - ISC

KW - JAK-STAT

KW - JNK

KW - microRNA

KW - midgut

KW - N

KW - Notch

KW - Proliferation

KW - Ras

KW - Regeneration

KW - Self-renewal

KW - Symmetric division

KW - Tissue damage

KW - Tumor

KW - Wg

KW - Wnt

KW - Yap

KW - Yki

UR - http://www.scopus.com/inward/record.url?scp=84964999876&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964999876&partnerID=8YFLogxK

U2 - 10.1007/s00018-016-2235-9

DO - 10.1007/s00018-016-2235-9

M3 - Article

SP - 1

EP - 13

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

ER -