Intestinal stem cells in the adult Drosophila midgut

Huaqi Jiang, Bruce A. Edgar

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

Drosophila has long been an excellent model organism for studying stem cell biology. Notably, studies of Drosophila's germline stem cells have been instrumental in developing the stem cell niche concept. The recent discovery of somatic stem cells in adult Drosophila, particularly the intestinal stem cells (ISCs) of the midgut, has established Drosophila as an exciting model to study stem cell-mediated adult tissue homeostasis and regeneration. Here, we review the major signaling pathways that regulate the self-renewal, proliferation and differentiation of Drosophila ISCs, discussing how this regulation maintains midgut homeostasis and mediates regeneration of the intestinal epithelium after injury.

Original languageEnglish (US)
Pages (from-to)2780-2788
Number of pages9
JournalExperimental Cell Research
Volume317
Issue number19
DOIs
StatePublished - Nov 15 2011

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Keywords

  • Drosophila midgut
  • Intestinal stem cell
  • Tissue homeostasis
  • Tissue regeneration

ASJC Scopus subject areas

  • Cell Biology

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