Intra-operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation

Mark G. Van Vledder, Emad M. Boctor, Lia R. Assumpcao, Hassan Rivaz, Pezhman Foroughi, Gregory D. Hager, Ulrike M. Hamper, Timothy M. Pawlik, Michael A. Choti

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Thermal ablation is an accepted therapy for selected hepatic malignancies. However, the reliability of thermal ablation is limited by the inability to accurately monitor and confirm completeness of tumour destruction in real time. We investigated the ability of ultrasound elasticity imaging (USEI) to monitor thermal ablation. Objectives: Capitalizing on the known increased stiffness that occurs with protein denaturation and dehydration during thermal therapy, we sought to investigate the feasibility and accuracy of USEI for monitoring of liver tumour ablation. Methods: A model for hepatic tumours was developed and elasticity images of liver ablation were acquired in in vivo animal studies, comparing the elasticity images to gross specimens. A clinical pilot study was conducted using USEI in nine patients undergoing open radiofrequency ablation for hepatic malignancies. The size and shape of thermal lesions on USEI were compared to B-mode ultrasound and post-ablation computed tomography (CT). Results: In both in vivo animal studies and in the clinical trial, the boundary of thermal lesions was significantly more conspicuous on USEI when compared with B-mode imaging. Animal studies demonstrated good correlation between the diameter of ablated lesions on USEI and the gross specimen (r = 0.81). Moreover, high-quality strain images were generated in real time during therapy. In patients undergoing tumour ablation, a good size correlation was observed between USEI and post-operative CT (r = 0.80). Conclusion: USEI can be a valuable tool for the accurate monitoring and real-time verification of successful thermal ablation of liver tumours.

Original languageEnglish (US)
Pages (from-to)717-723
Number of pages7
JournalHPB
Volume12
Issue number10
DOIs
StatePublished - Dec 2010

Fingerprint

Elasticity
Ultrasonography
Hot Temperature
Liver
Neoplasms
Tomography
Protein Denaturation
Dehydration
Therapeutics
Clinical Trials

Keywords

  • adiological intervention/treatment
  • colorectal metastases
  • hepatocellular carcinoma
  • liver cancer
  • palliation
  • radio frequency

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Van Vledder, M. G., Boctor, E. M., Assumpcao, L. R., Rivaz, H., Foroughi, P., Hager, G. D., ... Choti, M. A. (2010). Intra-operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation. HPB, 12(10), 717-723. https://doi.org/10.1111/j.1477-2574.2010.00247.x

Intra-operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation. / Van Vledder, Mark G.; Boctor, Emad M.; Assumpcao, Lia R.; Rivaz, Hassan; Foroughi, Pezhman; Hager, Gregory D.; Hamper, Ulrike M.; Pawlik, Timothy M.; Choti, Michael A.

In: HPB, Vol. 12, No. 10, 12.2010, p. 717-723.

Research output: Contribution to journalArticle

Van Vledder, MG, Boctor, EM, Assumpcao, LR, Rivaz, H, Foroughi, P, Hager, GD, Hamper, UM, Pawlik, TM & Choti, MA 2010, 'Intra-operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation', HPB, vol. 12, no. 10, pp. 717-723. https://doi.org/10.1111/j.1477-2574.2010.00247.x
Van Vledder MG, Boctor EM, Assumpcao LR, Rivaz H, Foroughi P, Hager GD et al. Intra-operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation. HPB. 2010 Dec;12(10):717-723. https://doi.org/10.1111/j.1477-2574.2010.00247.x
Van Vledder, Mark G. ; Boctor, Emad M. ; Assumpcao, Lia R. ; Rivaz, Hassan ; Foroughi, Pezhman ; Hager, Gregory D. ; Hamper, Ulrike M. ; Pawlik, Timothy M. ; Choti, Michael A. / Intra-operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation. In: HPB. 2010 ; Vol. 12, No. 10. pp. 717-723.
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