TY - JOUR
T1 - Intra-reader reliability of FDG PET volumetric tumor parameters
T2 - Effects of primary tumor size and segmentation methods
AU - Shah, B.
AU - Srivastava, N.
AU - Hirsch, A. E.
AU - Mercier, G.
AU - Subramaniam, R. M.
N1 - Funding Information:
Fig. 4 Intra-reader reliability of segmentations of TGA: patients were divided into those with a mean MTV \ 10 ml and 10 ml or greater. The bias was smaller for larger tumors (2.42–6.32 %) than smaller tumors (-4.26 to 16 %), though not statistically significant Acknowledgments Rathan Subramaniam was supported by a GE-AUR Research fellowship and received Siemens molecular imaging and MJ Fox foundation research grants.
PY - 2012/11
Y1 - 2012/11
N2 - Objective To establish the effects of size and segmentation methods on intra-reader reliability of primary tumor metabolic tumor volume (MTV) and total glycolytic activity (TGA) in human solid tumors. Methods This is a retrospective study of 121 patients who had a baseline FDG PET/CT scan for oncologic staging. Volumetric parameter readings were performed in random order on two separate occasions, 12 weeks apart, by the same reader. The MTV and TGA were segmented using gradient and fixed maximum standardized uptake value (SUVmax) threshold methods. Intra-reader reliability was established by the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Results The biases for MTV were 2.95, 14.76 and 11.13 % for gradient segmentation, 38 and 50 % SUVmax fixed threshold segmentations, respectively (p<0.0001). For TGA, the corresponding biases were 0.76, 10.36 and 7.46 % (p<0.0001). There were no statistically significant differences in the biases between the first and second reads for MTV segmented for small and large volume tumors by the gradient method (p<0.34) or 50 % SUVmax threshold segmentation (p<0.08). However, there were statistically significant differences in the corresponding biases for the 38 % SUVmax threshold segmentation (p<0.04). There were no statistically significant differences in the biases between the first and second reads for TGA segmented for small and large volume tumors (p<0.98). Conclusion Intra-reader reliability for primary tumor FDG MTV and TGA is affected by the tumor size and segmentation methods. The segmentation bias was smaller for gradient method than percentage fixed threshold method for MTV. The segmentation biases were smaller for TGA than MTV.
AB - Objective To establish the effects of size and segmentation methods on intra-reader reliability of primary tumor metabolic tumor volume (MTV) and total glycolytic activity (TGA) in human solid tumors. Methods This is a retrospective study of 121 patients who had a baseline FDG PET/CT scan for oncologic staging. Volumetric parameter readings were performed in random order on two separate occasions, 12 weeks apart, by the same reader. The MTV and TGA were segmented using gradient and fixed maximum standardized uptake value (SUVmax) threshold methods. Intra-reader reliability was established by the intraclass correlation coefficient (ICC) and Bland-Altman analysis. Results The biases for MTV were 2.95, 14.76 and 11.13 % for gradient segmentation, 38 and 50 % SUVmax fixed threshold segmentations, respectively (p<0.0001). For TGA, the corresponding biases were 0.76, 10.36 and 7.46 % (p<0.0001). There were no statistically significant differences in the biases between the first and second reads for MTV segmented for small and large volume tumors by the gradient method (p<0.34) or 50 % SUVmax threshold segmentation (p<0.08). However, there were statistically significant differences in the corresponding biases for the 38 % SUVmax threshold segmentation (p<0.04). There were no statistically significant differences in the biases between the first and second reads for TGA segmented for small and large volume tumors (p<0.98). Conclusion Intra-reader reliability for primary tumor FDG MTV and TGA is affected by the tumor size and segmentation methods. The segmentation bias was smaller for gradient method than percentage fixed threshold method for MTV. The segmentation biases were smaller for TGA than MTV.
KW - Metabolic tumor volume
KW - Reader reliability
KW - Total glycolytic activity
UR - http://www.scopus.com/inward/record.url?scp=84872101187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872101187&partnerID=8YFLogxK
U2 - 10.1007/s12149-012-0630-3
DO - 10.1007/s12149-012-0630-3
M3 - Article
C2 - 22797818
AN - SCOPUS:84872101187
SN - 0914-7187
VL - 26
SP - 707
EP - 714
JO - Annals of Nuclear Medicine
JF - Annals of Nuclear Medicine
IS - 9
ER -