TY - JOUR
T1 - Intraarterial drug abuse
T2 - New treatment options
AU - Silverman, Steven H.
AU - Turner, William W.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1991/7
Y1 - 1991/7
N2 - Accidental, intraarterial injections of abused substances continue to be difficult management problems because of severe vascular complications. Vasospasm probably plays an important role in the pathophysiology of this injury, in addition to the more accepted roles of thrombosis and endarteritis. Three patients with severe, upper extremity ischemia after intraarterial injection of heroin, methamphetamine, and meperidine were treated with intraarterial tolazoline and streptokinase, along with intravenous heparin. All three patients had improved perfusion, assessed both clinically and by angiography. The responses to treatment in these patients demonstrated the roles of vasospasm and thrombosis in the origin of this injury and the therapeutic benefits of appropriately administered vasodilators and thrombolytic agents.
AB - Accidental, intraarterial injections of abused substances continue to be difficult management problems because of severe vascular complications. Vasospasm probably plays an important role in the pathophysiology of this injury, in addition to the more accepted roles of thrombosis and endarteritis. Three patients with severe, upper extremity ischemia after intraarterial injection of heroin, methamphetamine, and meperidine were treated with intraarterial tolazoline and streptokinase, along with intravenous heparin. All three patients had improved perfusion, assessed both clinically and by angiography. The responses to treatment in these patients demonstrated the roles of vasospasm and thrombosis in the origin of this injury and the therapeutic benefits of appropriately administered vasodilators and thrombolytic agents.
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U2 - 10.1016/0741-5214(91)90162-N
DO - 10.1016/0741-5214(91)90162-N
M3 - Article
C2 - 2061951
AN - SCOPUS:0025916941
SN - 0741-5214
VL - 14
SP - 111
EP - 116
JO - Journal of vascular surgery
JF - Journal of vascular surgery
IS - 1
ER -