Intracellular transport of class II MHC molecules directed by invariant chain

Vincent Lotteau, Luc Teyton, Annick Peleraux, Tommy Nilsson, Lars Karlsson, Sandra L. Schmid, Vito Quaranta, Per A. Peterson

Research output: Contribution to journalArticle

413 Citations (Scopus)

Abstract

Three structural motifs in the invariant chain (Ii) control the intracellular transport of class II major histocompatibility complex molecules. An endoplasmic reticulum retention signal in the full-length Ii suggests a role for Ii in the α-β heterodimer assembly. Another signal motif directs a truncated Ii, alone or associated with individual class II chains, to a degradation compartment by a pathway circumventing the Golgi. When this truncated Ii binds α-β dimers, a third signal dominates, directing the complex by way of the Golgi to vesicles in the cell periphery, which may represent a subcompartment of recycling endosomes.

Original languageEnglish (US)
Pages (from-to)600-605
Number of pages6
JournalNature
Volume348
Issue number6302
StatePublished - Dec 13 1990

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Endosomes
Golgi Apparatus
Major Histocompatibility Complex
Endoplasmic Reticulum
invariant chain

ASJC Scopus subject areas

  • General

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Lotteau, V., Teyton, L., Peleraux, A., Nilsson, T., Karlsson, L., Schmid, S. L., ... Peterson, P. A. (1990). Intracellular transport of class II MHC molecules directed by invariant chain. Nature, 348(6302), 600-605.

Intracellular transport of class II MHC molecules directed by invariant chain. / Lotteau, Vincent; Teyton, Luc; Peleraux, Annick; Nilsson, Tommy; Karlsson, Lars; Schmid, Sandra L.; Quaranta, Vito; Peterson, Per A.

In: Nature, Vol. 348, No. 6302, 13.12.1990, p. 600-605.

Research output: Contribution to journalArticle

Lotteau, V, Teyton, L, Peleraux, A, Nilsson, T, Karlsson, L, Schmid, SL, Quaranta, V & Peterson, PA 1990, 'Intracellular transport of class II MHC molecules directed by invariant chain', Nature, vol. 348, no. 6302, pp. 600-605.
Lotteau V, Teyton L, Peleraux A, Nilsson T, Karlsson L, Schmid SL et al. Intracellular transport of class II MHC molecules directed by invariant chain. Nature. 1990 Dec 13;348(6302):600-605.
Lotteau, Vincent ; Teyton, Luc ; Peleraux, Annick ; Nilsson, Tommy ; Karlsson, Lars ; Schmid, Sandra L. ; Quaranta, Vito ; Peterson, Per A. / Intracellular transport of class II MHC molecules directed by invariant chain. In: Nature. 1990 ; Vol. 348, No. 6302. pp. 600-605.
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