Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes

M. O. McCarron; K. L. Hoffmann; D. M. DeLong; L. Gray; A. M. Saunders; M. J. Alberts

doi:10.1212/wnl.53.9.2176

Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes

M. O. McCarron, K. L. Hoffmann, D. M. DeLong, L. Gray, A. M. Saunders, M. J. Alberts

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71 Scopus citations

Abstract

We investigated whether early hematoma or edema volumes could explain the adverse association between APOE ε4 and survival in intracerebral hemorrhage. Among 102 patients, ε4 carriers had a higher mortality rate than non-ε4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm³ versus 27.1 cm³, p < 0.001) and edema volumes (37.5 cm³ versus 17.1 cm³, p < 0.01, but these were not associated with ε4 after adjusting for race, age, and type of hemorrhage.

Original language	English (US)
Pages (from-to)	2176-2179
Number of pages	4
Journal	Neurology
Volume	53
Issue number	9
DOIs	https://doi.org/10.1212/wnl.53.9.2176
State	Published - Dec 10 1999

Keywords

-Apolipoprotein E
Intracerebral hemorrhage
Outcome

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.53.9.2176

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abstract = "We investigated whether early hematoma or edema volumes could explain the adverse association between APOE ε4 and survival in intracerebral hemorrhage. Among 102 patients, ε4 carriers had a higher mortality rate than non-ε4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p < 0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p < 0.01, but these were not associated with ε4 after adjusting for race, age, and type of hemorrhage.",

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T2 - Apolipoprotein E genotype, hematoma, and edema volumes

AU - McCarron, M. O.

AU - Hoffmann, K. L.

AU - DeLong, D. M.

AU - Gray, L.

AU - Saunders, A. M.

AU - Alberts, M. J.

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AB - We investigated whether early hematoma or edema volumes could explain the adverse association between APOE ε4 and survival in intracerebral hemorrhage. Among 102 patients, ε4 carriers had a higher mortality rate than non-ε4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p < 0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p < 0.01, but these were not associated with ε4 after adjusting for race, age, and type of hemorrhage.

KW - -Apolipoprotein E

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KW - Outcome

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Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes

Abstract

Keywords

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