Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes

M. O. McCarron, K. L. Hoffmann, D. M. DeLong, L. Gray, A. M. Saunders, M. J. Alberts

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

We investigated whether early hematoma or edema volumes could explain the adverse association between APOE ε4 and survival in intracerebral hemorrhage. Among 102 patients, ε4 carriers had a higher mortality rate than non-ε4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p < 0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p < 0.01, but these were not associated with ε4 after adjusting for race, age, and type of hemorrhage.

Original languageEnglish (US)
Pages (from-to)2176-2179
Number of pages4
JournalNeurology
Volume53
Issue number9
StatePublished - Dec 10 1999

Keywords

  • -Apolipoprotein E
  • Intracerebral hemorrhage
  • Outcome

ASJC Scopus subject areas

  • Clinical Neurology

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    McCarron, M. O., Hoffmann, K. L., DeLong, D. M., Gray, L., Saunders, A. M., & Alberts, M. J. (1999). Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes. Neurology, 53(9), 2176-2179.