Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes

M. O. McCarron, K. L. Hoffmann, D. M. DeLong, L. Gray, A. M. Saunders, M. J. Alberts

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67 Scopus citations

Abstract

We investigated whether early hematoma or edema volumes could explain the adverse association between APOE ε4 and survival in intracerebral hemorrhage. Among 102 patients, ε4 carriers had a higher mortality rate than non-ε4 carriers (38 versus 24%, p = 0.05). Nonsurvivors had larger hematoma (75.5 cm3 versus 27.1 cm3, p < 0.001) and edema volumes (37.5 cm3 versus 17.1 cm3, p < 0.01, but these were not associated with ε4 after adjusting for race, age, and type of hemorrhage.

Original languageEnglish (US)
Pages (from-to)2176-2179
Number of pages4
JournalNeurology
Volume53
Issue number9
Publication statusPublished - Dec 10 1999

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Keywords

  • -Apolipoprotein E
  • Intracerebral hemorrhage
  • Outcome

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

McCarron, M. O., Hoffmann, K. L., DeLong, D. M., Gray, L., Saunders, A. M., & Alberts, M. J. (1999). Intracerebral hemorrhage outcome: Apolipoprotein E genotype, hematoma, and edema volumes. Neurology, 53(9), 2176-2179.