Intraductal Carcinoma of the Pancreas

S. Milchgrub, M. Campuzano, J. Casillas, J. Albores-Saavedra

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Four multicentric intraductal papillary carcinomas arising in the main pancreatic duct are presented. Three of the neoplasms showed stromal invasion and metastasized to regional lymph nodes. Three patients had a long history of epigastric pain, confirming the progressive slow growth and less aggressive nature of this clinico‐pathologic entity. Histologically, all tumors were papillary, and three also showed a pseudocribriform pattern. Individual cells exhibited a range of atypia from mild to overt malignant change. Focal intestinal‐differentiation was recognized in two tumors. Despite the well‐differentiated appearance of these tumors, two patients died within 1 year of surgery. One patient with an entirely intraductal carcinoma is alive and well 3 years after surgical treatment. The fourth patient who had lymph node metastasis is alive 6 months after a Whipple's procedure.

Original languageEnglish (US)
Pages (from-to)651-656
Number of pages6
JournalCancer
Volume69
Issue number3
DOIs
StatePublished - Feb 1 1992

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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