Intramolecular N-Me and N-H aminoetherification for the synthesis ofN-unprotected 3-amino-O-heterocycles

Mahesh P. Paudyal, Mingliang Wang, Juha H. Siitonen, Yimin Hu, Muhammed Yousufuddin, Hong C. Shen, John R. Falck, László Kürti

Research output: Contribution to journalArticlepeer-review

Abstract

A mild Rh-catalyzed method for synthesis of cyclic unprotected N-Me and N-H 2,3-aminoethers using an olefin aziridination-aziridine ring-opening domino reaction has been developed. The method is readily applicable to the stereocontrolled synthesis of a variety of 2,3-disubstituted aminoether O-heterocyclic scaffolds, including tetrahydrofurans, tetrahydropyrans and chromanes.

Original languageEnglish (US)
Pages (from-to)557-560
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume19
Issue number3
DOIs
StatePublished - Jan 21 2021

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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