Intramolecular Palladium-Catalyzed Oxidative Amination of Furans: Synthesis of Functionalized Indoles

Anton S. Makarov, Maxim G. Uchuskin, Vladimir Gevorgyan

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Unconventional modification of palladium-catalyzed oxidative amination where a furan ring serves as a masked olefin is described. The designed chemical process provides 2-(2-acylvinyl)indole derivatives with up to a 93% yield and excellent E-selectivity. A highly reactive α,β-unsaturated carbonyl moiety of the obtained compounds allows for accessing various heteroaromatic scaffolds through simple synthetic procedures.

Original languageEnglish (US)
Pages (from-to)14010-14021
Number of pages12
JournalJournal of Organic Chemistry
Volume83
Issue number22
DOIs
StatePublished - Nov 16 2018
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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