Intramolecular transannulation of alkynyl triazoles via alkyne-carbene metathesis step: Access to fused pyrroles

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

An intramolecular Rh-catalyzed transannulation reaction of alkynyl triazoles has been developed. This method allows efficient construction of various 5,5-fused pyrroles, including tetrahydropyrrolo and spiro systems. The method demonstrates excellent functional group compatibility. A rhodium carbene-alkyne metathesis mechanism is proposed for this transformation.

Original languageEnglish (US)
Pages (from-to)5394-5396
Number of pages3
JournalOrganic Letters
Volume15
Issue number20
DOIs
StatePublished - Oct 18 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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