Intraoperative cytologic diagnosis of breast sentinel lymph nodes in the routine, nonacademic setting

A highly specific test with limited sensitivity

Craig E. Litz, Peter D. Beitsch, Gory A. Roberts, Gene Ewing, Edward Clifford

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Intraoperative determination of metastatic breast carcinoma in sentinel lymph nodes (SLNs) by cytologic methods has been proposed as highly specific and sensitive. Much of these data are derived from academic institutes with highly trained personnel and without axillary dissection occurring as a direct result of the intraoperative interpretation. This prospective study was undertaken to assess the sensitivity and specificity of cytology in the routine, private-practice, intraoperative setting. A total of 207 SLNs from 96 breast carcinoma patients were evaluated by intraoperative cytologic preparations by general surgical pathologists; positive results led to axillary lymphadenectomy. Ten nodes were positive by intraoperative cytology (IC). Permanent section analysis confirmed the presence of carcinoma in the IC-positive cases and documented carcinoma in 19 of the IC-negative cases. IC sensitivity and specificity were 34% and 100%, respectively. False-negative IC interpretations occurred in nodes with occult micrometastases (12 of 19 nodes) and tabular carcinoma (6 of 19 nodes). Only one of eight grossly positive sentinel nodes resulted in a false-negative IC. While near-perfect specificity and high sensitivity can be achieved with grossly positive sentinel nodes by IC, sensitivity is quite low in cases with micrometastatic and tabular carcinoma.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalBreast Journal
Volume10
Issue number5
DOIs
StatePublished - Sep 2004

Fingerprint

Cell Biology
Breast
Carcinoma
Sensitivity and Specificity
Breast Neoplasms
Neoplasm Micrometastasis
Sentinel Lymph Node
Private Practice
Lymph Node Excision
Dissection
Prospective Studies

Keywords

  • Breast carcinoma
  • Cytology
  • Imprint
  • Intraoperative diagnosis
  • Sentinel lymph node

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology

Cite this

Intraoperative cytologic diagnosis of breast sentinel lymph nodes in the routine, nonacademic setting : A highly specific test with limited sensitivity. / Litz, Craig E.; Beitsch, Peter D.; Roberts, Gory A.; Ewing, Gene; Clifford, Edward.

In: Breast Journal, Vol. 10, No. 5, 09.2004, p. 383-387.

Research output: Contribution to journalArticle

Litz, Craig E. ; Beitsch, Peter D. ; Roberts, Gory A. ; Ewing, Gene ; Clifford, Edward. / Intraoperative cytologic diagnosis of breast sentinel lymph nodes in the routine, nonacademic setting : A highly specific test with limited sensitivity. In: Breast Journal. 2004 ; Vol. 10, No. 5. pp. 383-387.
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