Intrapartum pharmacokinetics of ticarcillin and clavulanic acid in serum as determined by high-pressure liquid chromatography

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Abstract

A high-pressure liquid chromatographic (HPLC) assay was developed for the determination of the epimeric distribution of ticarcillin and a derivatization method was used for the HPLC assay of clavulanic acid. Fifty-five women in labor who underwent cesarean section for cephalopelvic disproportion were given 3.1 gm of Timentin (ticarcillin 3.0 gm and 100 mg of clavulanic acid) intravenously, and the total serum ticarcillin and clavulanic acid levels measured throughout four hours. The epimeric distribution of ticarcillin, and the ratio of ticarcillin to clavulanic acid was also determined. The mean peak serum concentration was 205.7 ± 89.4 μg/ml at 30 minutes post dose and there were no changes in the epimeric distribution of ticarcillin. The simultaneous mean peak clavulanic acid serum concentration was 3.6 ± 1.6 μg/ml. The half-life of ticarcillin and clavulanic acid was 49.9 ± 16.3 minutes, and 67.9 ± 24.4 minutes respectively. There was a significant difference in these half-lives compared to non-pregnant individuals.

Original languageEnglish (US)
Pages (from-to)419-426
Number of pages8
JournalAdvances in Therapy
Volume1
Issue number6
StatePublished - 1984

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Ticarcillin
Clavulanic Acid
Pharmacokinetics
High Pressure Liquid Chromatography
Serum
Cephalopelvic Disproportion
Pressure
Cesarean Section
Half-Life
ticarcillin-clavulanic acid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Intrapartum pharmacokinetics of ticarcillin and clavulanic acid in serum as determined by high-pressure liquid chromatography",
abstract = "A high-pressure liquid chromatographic (HPLC) assay was developed for the determination of the epimeric distribution of ticarcillin and a derivatization method was used for the HPLC assay of clavulanic acid. Fifty-five women in labor who underwent cesarean section for cephalopelvic disproportion were given 3.1 gm of Timentin (ticarcillin 3.0 gm and 100 mg of clavulanic acid) intravenously, and the total serum ticarcillin and clavulanic acid levels measured throughout four hours. The epimeric distribution of ticarcillin, and the ratio of ticarcillin to clavulanic acid was also determined. The mean peak serum concentration was 205.7 ± 89.4 μg/ml at 30 minutes post dose and there were no changes in the epimeric distribution of ticarcillin. The simultaneous mean peak clavulanic acid serum concentration was 3.6 ± 1.6 μg/ml. The half-life of ticarcillin and clavulanic acid was 49.9 ± 16.3 minutes, and 67.9 ± 24.4 minutes respectively. There was a significant difference in these half-lives compared to non-pregnant individuals.",
author = "Bawdon, {R. E.} and Leveno, {K. L.} and Cunningham, {F. G.}",
year = "1984",
language = "English (US)",
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pages = "419--426",
journal = "Advances in Therapy",
issn = "0741-238X",
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T1 - Intrapartum pharmacokinetics of ticarcillin and clavulanic acid in serum as determined by high-pressure liquid chromatography

AU - Bawdon, R. E.

AU - Leveno, K. L.

AU - Cunningham, F. G.

PY - 1984

Y1 - 1984

N2 - A high-pressure liquid chromatographic (HPLC) assay was developed for the determination of the epimeric distribution of ticarcillin and a derivatization method was used for the HPLC assay of clavulanic acid. Fifty-five women in labor who underwent cesarean section for cephalopelvic disproportion were given 3.1 gm of Timentin (ticarcillin 3.0 gm and 100 mg of clavulanic acid) intravenously, and the total serum ticarcillin and clavulanic acid levels measured throughout four hours. The epimeric distribution of ticarcillin, and the ratio of ticarcillin to clavulanic acid was also determined. The mean peak serum concentration was 205.7 ± 89.4 μg/ml at 30 minutes post dose and there were no changes in the epimeric distribution of ticarcillin. The simultaneous mean peak clavulanic acid serum concentration was 3.6 ± 1.6 μg/ml. The half-life of ticarcillin and clavulanic acid was 49.9 ± 16.3 minutes, and 67.9 ± 24.4 minutes respectively. There was a significant difference in these half-lives compared to non-pregnant individuals.

AB - A high-pressure liquid chromatographic (HPLC) assay was developed for the determination of the epimeric distribution of ticarcillin and a derivatization method was used for the HPLC assay of clavulanic acid. Fifty-five women in labor who underwent cesarean section for cephalopelvic disproportion were given 3.1 gm of Timentin (ticarcillin 3.0 gm and 100 mg of clavulanic acid) intravenously, and the total serum ticarcillin and clavulanic acid levels measured throughout four hours. The epimeric distribution of ticarcillin, and the ratio of ticarcillin to clavulanic acid was also determined. The mean peak serum concentration was 205.7 ± 89.4 μg/ml at 30 minutes post dose and there were no changes in the epimeric distribution of ticarcillin. The simultaneous mean peak clavulanic acid serum concentration was 3.6 ± 1.6 μg/ml. The half-life of ticarcillin and clavulanic acid was 49.9 ± 16.3 minutes, and 67.9 ± 24.4 minutes respectively. There was a significant difference in these half-lives compared to non-pregnant individuals.

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