TY - JOUR
T1 - Intrapartum prophylaxis with ceftriaxone decreases rates of bacterial colonization and early-onset infection in newborns
AU - Sáez-Llorens, Xavier
AU - Ah-Chu, Maria Sabina
AU - Castaño, Elizabeth
AU - Cortés, Lourdes
AU - Torres, Antonio
AU - Suárez, Marixcel
AU - Bissot, Alberto
AU - Reyes, Winston
AU - Karp, Warren B.
AU - McCracken, George H.
N1 - Funding Information:
Received 18 January 1995; revised 4 May 1995. Grant support: Supported in part by Roche Laboratories, Nutley, NJ. Correspondence: Dr. Xavier Saez-Llorens, Professor of Pediatrics and Infectious Diseases, PTY-226, P.O. Box 02-5275, Miami, Florida 33102-5275.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1995/10
Y1 - 1995/10
N2 - Because of high rates of neonatal gram-negative sepsis in many Latin American countries, we prospectively enrolled 784 high-risk pregnant women in a study designed to evaluate the effect of a single 1-g dose of ceftriaxone (n = 390) vs. that of no antibiotic prophylaxis (n = 394) on oral, rectal, and umbilical colonization and fatality rates among newborn infants. The mean ceftriaxone concentration in cord blood samples was 26 μg/mL (range, 9–40 μg/mL). Compared with infants of untreated mothers, children born to women who were given ceftriaxone were colonized at a lesser rate by gram-negative bacilli (54% vs. 35%; P <.001) and by group B streptococci (54% vs. 21%; P =.03) and endured significantly fewer sepsis-like illnesses in the first 5 days of life (8.1% vs. 3.1%; P =.004). There was also a tendency for them to have fewer episodes of culture-proven early-onset sepsis (2.8% vs. 0.5%; P =.06). Sepsis-related case-fatality rates (0.8% and 0.3%, respectively) were not significantly different. Although intrapartum administration of a single dose of ceftriaxone to high-risk mothers could be a safe and potentially useful strategy for reducing early-onset neonatal infections, additional information is required before this approach can be recommended for routine prophylaxis.
AB - Because of high rates of neonatal gram-negative sepsis in many Latin American countries, we prospectively enrolled 784 high-risk pregnant women in a study designed to evaluate the effect of a single 1-g dose of ceftriaxone (n = 390) vs. that of no antibiotic prophylaxis (n = 394) on oral, rectal, and umbilical colonization and fatality rates among newborn infants. The mean ceftriaxone concentration in cord blood samples was 26 μg/mL (range, 9–40 μg/mL). Compared with infants of untreated mothers, children born to women who were given ceftriaxone were colonized at a lesser rate by gram-negative bacilli (54% vs. 35%; P <.001) and by group B streptococci (54% vs. 21%; P =.03) and endured significantly fewer sepsis-like illnesses in the first 5 days of life (8.1% vs. 3.1%; P =.004). There was also a tendency for them to have fewer episodes of culture-proven early-onset sepsis (2.8% vs. 0.5%; P =.06). Sepsis-related case-fatality rates (0.8% and 0.3%, respectively) were not significantly different. Although intrapartum administration of a single dose of ceftriaxone to high-risk mothers could be a safe and potentially useful strategy for reducing early-onset neonatal infections, additional information is required before this approach can be recommended for routine prophylaxis.
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U2 - 10.1093/clinids/21.4.876
DO - 10.1093/clinids/21.4.876
M3 - Article
C2 - 8645833
AN - SCOPUS:0028801389
SN - 1058-4838
VL - 21
SP - 876
EP - 880
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 4
ER -