Intravenous γ-globulin use in children with Kawasaki disease

S. A. Plotkin; R. S. Daum; G. S. Giebink; C. B. Hall; M. Lepow; E. K. Marcuse; G. H. McCracken; C. F. Phillips; G. B. Scott; H. T. Wright; G. Peter; A. R. Hinman; P. Parkman; R. Gold; J. G. Easton

Intravenous γ-globulin use in children with Kawasaki disease

S. A. Plotkin, R. S. Daum, G. S. Giebink, C. B. Hall, M. Lepow, E. K. Marcuse, G. H. McCracken, C. F. Phillips, G. B. Scott, H. T. Wright, G. Peter, A. R. Hinman, P. Parkman, R. Gold, J. G. Easton

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11 Scopus citations

Abstract

A recent controlled American trial of treatment for Kawasaki disease compared the use of acetylsalicylic acid (aspirin) alone v aspirin at the same dose plus a single preparation of IV γ-globulin, which is not currently licensed in the United States. The dosage of IV γ-globulin was 400 mg/kg/d for four days, and the dosage of aspirin was 80 to 100 mg/kg/d for as many as 8 weeks. The results indicated that, if administered within ten days of onset of fever, the combined treatment significantly lowered the prevalence of coronary artery dilation and aneurysms detected at 2 and 7 weeks postenrollment. The IV γ-globulin-treated group showed significant and rapid reduction in fever, WBC count, and generalized inflammatory signs. Prior studies in Japan also showed benefit from IV γ-globulin.

Original language	English (US)
Pages (from-to)	122
Number of pages	1
Journal	Pediatrics
Volume	82
Issue number	1
State	Published - 1988

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Cite this

@article{19862598bb864b419d440f13df3aeeeb,

title = "Intravenous γ-globulin use in children with Kawasaki disease",

abstract = "A recent controlled American trial of treatment for Kawasaki disease compared the use of acetylsalicylic acid (aspirin) alone v aspirin at the same dose plus a single preparation of IV γ-globulin, which is not currently licensed in the United States. The dosage of IV γ-globulin was 400 mg/kg/d for four days, and the dosage of aspirin was 80 to 100 mg/kg/d for as many as 8 weeks. The results indicated that, if administered within ten days of onset of fever, the combined treatment significantly lowered the prevalence of coronary artery dilation and aneurysms detected at 2 and 7 weeks postenrollment. The IV γ-globulin-treated group showed significant and rapid reduction in fever, WBC count, and generalized inflammatory signs. Prior studies in Japan also showed benefit from IV γ-globulin.",

author = "Plotkin, {S. A.} and Daum, {R. S.} and Giebink, {G. S.} and Hall, {C. B.} and M. Lepow and Marcuse, {E. K.} and McCracken, {G. H.} and Phillips, {C. F.} and Scott, {G. B.} and Wright, {H. T.} and G. Peter and Hinman, {A. R.} and P. Parkman and R. Gold and Easton, {J. G.}",

year = "1988",

language = "English (US)",

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journal = "Pediatrics",

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T1 - Intravenous γ-globulin use in children with Kawasaki disease

AU - Plotkin, S. A.

AU - Daum, R. S.

AU - Giebink, G. S.

AU - Hall, C. B.

AU - Lepow, M.

AU - Marcuse, E. K.

AU - McCracken, G. H.

AU - Phillips, C. F.

AU - Scott, G. B.

AU - Wright, H. T.

AU - Peter, G.

AU - Hinman, A. R.

AU - Parkman, P.

AU - Gold, R.

AU - Easton, J. G.

PY - 1988

Y1 - 1988

N2 - A recent controlled American trial of treatment for Kawasaki disease compared the use of acetylsalicylic acid (aspirin) alone v aspirin at the same dose plus a single preparation of IV γ-globulin, which is not currently licensed in the United States. The dosage of IV γ-globulin was 400 mg/kg/d for four days, and the dosage of aspirin was 80 to 100 mg/kg/d for as many as 8 weeks. The results indicated that, if administered within ten days of onset of fever, the combined treatment significantly lowered the prevalence of coronary artery dilation and aneurysms detected at 2 and 7 weeks postenrollment. The IV γ-globulin-treated group showed significant and rapid reduction in fever, WBC count, and generalized inflammatory signs. Prior studies in Japan also showed benefit from IV γ-globulin.

AB - A recent controlled American trial of treatment for Kawasaki disease compared the use of acetylsalicylic acid (aspirin) alone v aspirin at the same dose plus a single preparation of IV γ-globulin, which is not currently licensed in the United States. The dosage of IV γ-globulin was 400 mg/kg/d for four days, and the dosage of aspirin was 80 to 100 mg/kg/d for as many as 8 weeks. The results indicated that, if administered within ten days of onset of fever, the combined treatment significantly lowered the prevalence of coronary artery dilation and aneurysms detected at 2 and 7 weeks postenrollment. The IV γ-globulin-treated group showed significant and rapid reduction in fever, WBC count, and generalized inflammatory signs. Prior studies in Japan also showed benefit from IV γ-globulin.

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Intravenous γ-globulin use in children with Kawasaki disease

Abstract

ASJC Scopus subject areas

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