Intravenous administration of kanamycin and gentamicin in newborn infants

G. H. McCracken, N. Threlkeld, M. L. Thomas

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The pharmacokinetics of kanamycin and gentamicin were studied after intramuscular (IM) and intravenous (IV) (constant infusion over 20 minutes) administration in newborn infants. The serum concentrations, halflives, area-under-the-curve values, and volumes of distribution were similar for each drug after both routes of administration. Based on these pharmacological similarities, it is likely that these aminoglycosides can be given safely and effectively as constant IV infusions to neonates in whom IM injections are not feasible.

Original languageEnglish (US)
Pages (from-to)463-466
Number of pages4
JournalPediatrics
Volume60
Issue number4
StatePublished - 1977

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Kanamycin
Gentamicins
Intravenous Infusions
Intravenous Administration
Newborn Infant
Intramuscular Injections
Aminoglycosides
Area Under Curve
Pharmacokinetics
Pharmacology
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Intravenous administration of kanamycin and gentamicin in newborn infants. / McCracken, G. H.; Threlkeld, N.; Thomas, M. L.

In: Pediatrics, Vol. 60, No. 4, 1977, p. 463-466.

Research output: Contribution to journalArticle

McCracken, GH, Threlkeld, N & Thomas, ML 1977, 'Intravenous administration of kanamycin and gentamicin in newborn infants', Pediatrics, vol. 60, no. 4, pp. 463-466.
McCracken, G. H. ; Threlkeld, N. ; Thomas, M. L. / Intravenous administration of kanamycin and gentamicin in newborn infants. In: Pediatrics. 1977 ; Vol. 60, No. 4. pp. 463-466.
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