Intravenous Ferric Carboxymaltose in Children with Iron Deficiency Anemia Who Respond Poorly to Oral Iron

Jacquelyn M. Powers, Mark Shamoun, Timothy L. McCavit, Leah Adix, George R. Buchanan

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Objective To assess the benefits and risks of intravenous (IV) ferric carboxymaltose (FCM) in children with iron deficiency anemia (IDA). Study design In a retrospective cohort study of patients seen at our center, we identified all FCM infusions in children with IDA over a 12-month period through a query of pharmacy records. Clinical data, including hematologic response and adverse effects, were extracted from the electronic medical record. Results A total of 116 IV FCM infusions were administered to 72 patients with IDA refractory to oral iron treatment (median age, 13.7 years; range, 9 months to 18 years). Median preinfusion and postinfusion hemoglobin values were 9.1 g/dL and 12.3 g/dL, respectively (at 4-12 weeks after the initial infusion; n = 53). Sixty-five patients (84%) experienced no adverse effects. Minor transient complications were encountered during or immediately after 7 infusions. Conclusion FCM administered as a short IV infusion without a test dose proved to be safe and highly effective in a small yet diverse population of infants, children, and adolescents with IDA refractory to oral iron therapy.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalJournal of Pediatrics
Volume180
DOIs
StatePublished - Jan 1 2017

Keywords

  • heavy menstrual bleeding
  • inflammatory bowel disease
  • menorrhagia
  • nutritional

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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