Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation

Robert Nee, Dennis Doppenschmidt, Daniel J. Donovan, Thomas C. Andrews

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.

Original languageEnglish (US)
Pages (from-to)286-288
Number of pages3
JournalAmerican Journal of Cardiology
Volume83
Issue number2
DOIs
StatePublished - Jan 15 1999

Fingerprint

Vitamin K 1
Warfarin
Intravenous Administration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation. / Nee, Robert; Doppenschmidt, Dennis; Donovan, Daniel J.; Andrews, Thomas C.

In: American Journal of Cardiology, Vol. 83, No. 2, 15.01.1999, p. 286-288.

Research output: Contribution to journalArticle

Nee, Robert ; Doppenschmidt, Dennis ; Donovan, Daniel J. ; Andrews, Thomas C. / Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation. In: American Journal of Cardiology. 1999 ; Vol. 83, No. 2. pp. 286-288.
@article{6cea6ab6f4ba431e8b7f096ab6cec15a,
title = "Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation",
abstract = "Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.",
author = "Robert Nee and Dennis Doppenschmidt and Donovan, {Daniel J.} and Andrews, {Thomas C.}",
year = "1999",
month = "1",
day = "15",
doi = "10.1016/S0002-9149(98)00842-X",
language = "English (US)",
volume = "83",
pages = "286--288",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Intravenous versus subcutaneous vitamin K1 in reversing excessive oral anticoagulation

AU - Nee, Robert

AU - Doppenschmidt, Dennis

AU - Donovan, Daniel J.

AU - Andrews, Thomas C.

PY - 1999/1/15

Y1 - 1999/1/15

N2 - Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.

AB - Our data suggest that compared with the subcutaneous route of administration, intravenous vitamin K1 results in a more prompt reduction in the international normalized ration. However, for most patients, subcutaneous vitamin K1 is an effective and safe alternative when used in conjunction with modification of subsequent warfarin dosing, because virtually all patients achieved a safe level of anticoagulation within 72 hours with this route of administration.

UR - http://www.scopus.com/inward/record.url?scp=0033556414&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033556414&partnerID=8YFLogxK

U2 - 10.1016/S0002-9149(98)00842-X

DO - 10.1016/S0002-9149(98)00842-X

M3 - Article

C2 - 10073841

AN - SCOPUS:0033556414

VL - 83

SP - 286

EP - 288

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 2

ER -