Intravesical oxybutynin chloride: Experience with 42 patients

Donald L. Weese, Deborah A. Roskamp, Gary E. Leach, Philippe E. Zimmern

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

To evaluate the efficacy of intravesical oxybutynin chloride, 42 patients who were incontinent secondary to uninhibited detrusor contractions and had failed oral anticholinergic therapy were begun on intravesical oxybutynin chloride. Indications for intravesical therapy were detrusor hyperreflexia (N = 20), detrusor instability (N = 19), and bowel/bladder overactivity after augmentation cystoplasty (N = 3). A 5-mg tablet dissolved in 30 cc of sterile water was instilled into the bladder two to three times daily via clean self Intermittent catheterization. With a mean follow-up of 18.4 months, no patient reported side effects as a result of the intravesical therapy. Nine patients (21 %) dropped out of the study due to inability to tolerate the catheterization or difficulty retaining the solution in the bladder. Eighteen of the 33 patients (55 % ) who followed the protocol experienced elimination or significant improvement of their incontinence. The results of the current study confirm the safety and usefulness of intravesical oxybutynin in treating uninhibited detrusor contractions in a difficult patient population.

Original languageEnglish (US)
Pages (from-to)527-530
Number of pages4
JournalUrology
Volume41
Issue number6
DOIs
StatePublished - 1993

Fingerprint

Urinary Bladder
Intermittent Urethral Catheterization
Abnormal Reflexes
Cholinergic Antagonists
Catheterization
Tablets
Therapeutics
oxybutynin
Safety
Water
Population

ASJC Scopus subject areas

  • Urology

Cite this

Intravesical oxybutynin chloride : Experience with 42 patients. / Weese, Donald L.; Roskamp, Deborah A.; Leach, Gary E.; Zimmern, Philippe E.

In: Urology, Vol. 41, No. 6, 1993, p. 527-530.

Research output: Contribution to journalArticle

Weese, Donald L. ; Roskamp, Deborah A. ; Leach, Gary E. ; Zimmern, Philippe E. / Intravesical oxybutynin chloride : Experience with 42 patients. In: Urology. 1993 ; Vol. 41, No. 6. pp. 527-530.
@article{280892f0571a40b7b73bbf02d9f943c8,
title = "Intravesical oxybutynin chloride: Experience with 42 patients",
abstract = "To evaluate the efficacy of intravesical oxybutynin chloride, 42 patients who were incontinent secondary to uninhibited detrusor contractions and had failed oral anticholinergic therapy were begun on intravesical oxybutynin chloride. Indications for intravesical therapy were detrusor hyperreflexia (N = 20), detrusor instability (N = 19), and bowel/bladder overactivity after augmentation cystoplasty (N = 3). A 5-mg tablet dissolved in 30 cc of sterile water was instilled into the bladder two to three times daily via clean self Intermittent catheterization. With a mean follow-up of 18.4 months, no patient reported side effects as a result of the intravesical therapy. Nine patients (21 {\%}) dropped out of the study due to inability to tolerate the catheterization or difficulty retaining the solution in the bladder. Eighteen of the 33 patients (55 {\%} ) who followed the protocol experienced elimination or significant improvement of their incontinence. The results of the current study confirm the safety and usefulness of intravesical oxybutynin in treating uninhibited detrusor contractions in a difficult patient population.",
author = "Weese, {Donald L.} and Roskamp, {Deborah A.} and Leach, {Gary E.} and Zimmern, {Philippe E.}",
year = "1993",
doi = "10.1016/0090-4295(93)90098-U",
language = "English (US)",
volume = "41",
pages = "527--530",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Intravesical oxybutynin chloride

T2 - Experience with 42 patients

AU - Weese, Donald L.

AU - Roskamp, Deborah A.

AU - Leach, Gary E.

AU - Zimmern, Philippe E.

PY - 1993

Y1 - 1993

N2 - To evaluate the efficacy of intravesical oxybutynin chloride, 42 patients who were incontinent secondary to uninhibited detrusor contractions and had failed oral anticholinergic therapy were begun on intravesical oxybutynin chloride. Indications for intravesical therapy were detrusor hyperreflexia (N = 20), detrusor instability (N = 19), and bowel/bladder overactivity after augmentation cystoplasty (N = 3). A 5-mg tablet dissolved in 30 cc of sterile water was instilled into the bladder two to three times daily via clean self Intermittent catheterization. With a mean follow-up of 18.4 months, no patient reported side effects as a result of the intravesical therapy. Nine patients (21 %) dropped out of the study due to inability to tolerate the catheterization or difficulty retaining the solution in the bladder. Eighteen of the 33 patients (55 % ) who followed the protocol experienced elimination or significant improvement of their incontinence. The results of the current study confirm the safety and usefulness of intravesical oxybutynin in treating uninhibited detrusor contractions in a difficult patient population.

AB - To evaluate the efficacy of intravesical oxybutynin chloride, 42 patients who were incontinent secondary to uninhibited detrusor contractions and had failed oral anticholinergic therapy were begun on intravesical oxybutynin chloride. Indications for intravesical therapy were detrusor hyperreflexia (N = 20), detrusor instability (N = 19), and bowel/bladder overactivity after augmentation cystoplasty (N = 3). A 5-mg tablet dissolved in 30 cc of sterile water was instilled into the bladder two to three times daily via clean self Intermittent catheterization. With a mean follow-up of 18.4 months, no patient reported side effects as a result of the intravesical therapy. Nine patients (21 %) dropped out of the study due to inability to tolerate the catheterization or difficulty retaining the solution in the bladder. Eighteen of the 33 patients (55 % ) who followed the protocol experienced elimination or significant improvement of their incontinence. The results of the current study confirm the safety and usefulness of intravesical oxybutynin in treating uninhibited detrusor contractions in a difficult patient population.

UR - http://www.scopus.com/inward/record.url?scp=0027241178&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027241178&partnerID=8YFLogxK

U2 - 10.1016/0090-4295(93)90098-U

DO - 10.1016/0090-4295(93)90098-U

M3 - Article

C2 - 8516987

AN - SCOPUS:0027241178

VL - 41

SP - 527

EP - 530

JO - Urology

JF - Urology

SN - 0090-4295

IS - 6

ER -