Intrinsic antiviral immunity

Research output: Contribution to journalArticle

234 Citations (Scopus)

Abstract

Intrinsic antiviral immunity refers to a form of innate immunity that directly restricts viral replication and assembly, thereby rendering a cell nonpermissive to a specific class or species of viruses. Intrinsic immunity is conferred by restriction factors that are mostly preexistent in certain cell types, although these factors can be further induced by viral infection. Intrinsic virus-restriction factors recognize specific viral components, but unlike other pattern-recognition receptors that inhibit viral infection indirectly by inducing interferons and other antiviral molecules, intrinsic antiviral factors block viral replication immediately and directly. This review focuses on recent advances in understanding of the roles of intrinsic antiviral factors that restrict infection by human immunodeficiency virus and influenza virus.

Original languageEnglish (US)
Pages (from-to)214-222
Number of pages9
JournalNature Immunology
Volume13
Issue number3
DOIs
StatePublished - Mar 2012

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Antiviral Agents
Immunity
Intrinsic Factor
Virus Diseases
Viruses
Pattern Recognition Receptors
Virus Assembly
Viral Structures
Orthomyxoviridae
Innate Immunity
Interferons
HIV
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Intrinsic antiviral immunity. / Yan, Nan; Chen, Zhijian J.

In: Nature Immunology, Vol. 13, No. 3, 03.2012, p. 214-222.

Research output: Contribution to journalArticle

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