Intrinsic neural activity differences among psychotic illnesses

Matthew E. Hudgens-Haney, Lauren E. Ethridge, Justin B. Knight, Jennifer E. Mcdowell, Sarah K. Keedy, Godfrey D. Pearlson, Carol A. Tamminga, Matcheri S. Keshavan, John A. Sweeney, Brett A. Clementz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Individuals with psychosis have been reported to show either reduced or augmented brain responses under seemingly similar conditions. It is likely that inconsistent baseline-adjustment methods are partly responsible for this discrepancy. Using steady-state stimuli during a pro/antisaccade task, this study addressed the relationship between nonspecific and stimulus-related neural activity, and how these activities are modulated as a function of cognitive demands. In 98 psychosis probands (schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis), neural activity was assessed during baseline and during a 5-s period in preparation for the pro/antisaccade task. To maximize the ability to identify meaningful differences between psychosis subtypes, analyses were conducted as a function of subgrouping probands by standard clinical diagnoses and neurobiological features. These psychosis "biotypes" were created using brain-based biomarkers, independent of symptomatology (Clementz et al., ). Psychosis probands as a whole showed poor antisaccade performance and diminished baseline oscillatory phase synchrony. Psychosis biotypes differed on both behavioral and brain measures, in ways predicted from Clementz et al. (). Two biotype groups showed similarly deficient behavior and baseline synchrony, despite diametrically opposed neural activity amplitudes. Another biotype subgroup was more similar to healthy individuals on behavioral and brain measures, despite the presence of psychosis. This study provides evidence that (a) consideration of baseline levels of activation and synchrony will be essential for a comprehensive understanding of neural response differences in psychosis, and (b) distinct psychosis subgroups exhibit reduced versus augmented intrinsic neural activity, despite cognitive performance and clinical similarities.

Original languageEnglish (US)
JournalPsychophysiology
DOIs
StateAccepted/In press - 2017

Fingerprint

Psychotic Disorders
Brain
Intrinsic
Psychosis
Illness
Social Adjustment
Aptitude
Bipolar Disorder
Cognition
Schizophrenia
Biomarkers

Keywords

  • Biomarkers
  • Bipolar disorder
  • Diagnosis
  • EEG
  • Psychosis
  • Schizophrenia
  • Steady-state

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Physiology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Physiology (medical)

Cite this

Hudgens-Haney, M. E., Ethridge, L. E., Knight, J. B., Mcdowell, J. E., Keedy, S. K., Pearlson, G. D., ... Clementz, B. A. (Accepted/In press). Intrinsic neural activity differences among psychotic illnesses. Psychophysiology. https://doi.org/10.1111/psyp.12875

Intrinsic neural activity differences among psychotic illnesses. / Hudgens-Haney, Matthew E.; Ethridge, Lauren E.; Knight, Justin B.; Mcdowell, Jennifer E.; Keedy, Sarah K.; Pearlson, Godfrey D.; Tamminga, Carol A.; Keshavan, Matcheri S.; Sweeney, John A.; Clementz, Brett A.

In: Psychophysiology, 2017.

Research output: Contribution to journalArticle

Hudgens-Haney, ME, Ethridge, LE, Knight, JB, Mcdowell, JE, Keedy, SK, Pearlson, GD, Tamminga, CA, Keshavan, MS, Sweeney, JA & Clementz, BA 2017, 'Intrinsic neural activity differences among psychotic illnesses', Psychophysiology. https://doi.org/10.1111/psyp.12875
Hudgens-Haney ME, Ethridge LE, Knight JB, Mcdowell JE, Keedy SK, Pearlson GD et al. Intrinsic neural activity differences among psychotic illnesses. Psychophysiology. 2017. https://doi.org/10.1111/psyp.12875
Hudgens-Haney, Matthew E. ; Ethridge, Lauren E. ; Knight, Justin B. ; Mcdowell, Jennifer E. ; Keedy, Sarah K. ; Pearlson, Godfrey D. ; Tamminga, Carol A. ; Keshavan, Matcheri S. ; Sweeney, John A. ; Clementz, Brett A. / Intrinsic neural activity differences among psychotic illnesses. In: Psychophysiology. 2017.
@article{4b79b61918c24b4d81b8c06776048508,
title = "Intrinsic neural activity differences among psychotic illnesses",
abstract = "Individuals with psychosis have been reported to show either reduced or augmented brain responses under seemingly similar conditions. It is likely that inconsistent baseline-adjustment methods are partly responsible for this discrepancy. Using steady-state stimuli during a pro/antisaccade task, this study addressed the relationship between nonspecific and stimulus-related neural activity, and how these activities are modulated as a function of cognitive demands. In 98 psychosis probands (schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis), neural activity was assessed during baseline and during a 5-s period in preparation for the pro/antisaccade task. To maximize the ability to identify meaningful differences between psychosis subtypes, analyses were conducted as a function of subgrouping probands by standard clinical diagnoses and neurobiological features. These psychosis {"}biotypes{"} were created using brain-based biomarkers, independent of symptomatology (Clementz et al., ). Psychosis probands as a whole showed poor antisaccade performance and diminished baseline oscillatory phase synchrony. Psychosis biotypes differed on both behavioral and brain measures, in ways predicted from Clementz et al. (). Two biotype groups showed similarly deficient behavior and baseline synchrony, despite diametrically opposed neural activity amplitudes. Another biotype subgroup was more similar to healthy individuals on behavioral and brain measures, despite the presence of psychosis. This study provides evidence that (a) consideration of baseline levels of activation and synchrony will be essential for a comprehensive understanding of neural response differences in psychosis, and (b) distinct psychosis subgroups exhibit reduced versus augmented intrinsic neural activity, despite cognitive performance and clinical similarities.",
keywords = "Biomarkers, Bipolar disorder, Diagnosis, EEG, Psychosis, Schizophrenia, Steady-state",
author = "Hudgens-Haney, {Matthew E.} and Ethridge, {Lauren E.} and Knight, {Justin B.} and Mcdowell, {Jennifer E.} and Keedy, {Sarah K.} and Pearlson, {Godfrey D.} and Tamminga, {Carol A.} and Keshavan, {Matcheri S.} and Sweeney, {John A.} and Clementz, {Brett A.}",
year = "2017",
doi = "10.1111/psyp.12875",
language = "English (US)",
journal = "Psychophysiology",
issn = "0048-5772",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Intrinsic neural activity differences among psychotic illnesses

AU - Hudgens-Haney, Matthew E.

AU - Ethridge, Lauren E.

AU - Knight, Justin B.

AU - Mcdowell, Jennifer E.

AU - Keedy, Sarah K.

AU - Pearlson, Godfrey D.

AU - Tamminga, Carol A.

AU - Keshavan, Matcheri S.

AU - Sweeney, John A.

AU - Clementz, Brett A.

PY - 2017

Y1 - 2017

N2 - Individuals with psychosis have been reported to show either reduced or augmented brain responses under seemingly similar conditions. It is likely that inconsistent baseline-adjustment methods are partly responsible for this discrepancy. Using steady-state stimuli during a pro/antisaccade task, this study addressed the relationship between nonspecific and stimulus-related neural activity, and how these activities are modulated as a function of cognitive demands. In 98 psychosis probands (schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis), neural activity was assessed during baseline and during a 5-s period in preparation for the pro/antisaccade task. To maximize the ability to identify meaningful differences between psychosis subtypes, analyses were conducted as a function of subgrouping probands by standard clinical diagnoses and neurobiological features. These psychosis "biotypes" were created using brain-based biomarkers, independent of symptomatology (Clementz et al., ). Psychosis probands as a whole showed poor antisaccade performance and diminished baseline oscillatory phase synchrony. Psychosis biotypes differed on both behavioral and brain measures, in ways predicted from Clementz et al. (). Two biotype groups showed similarly deficient behavior and baseline synchrony, despite diametrically opposed neural activity amplitudes. Another biotype subgroup was more similar to healthy individuals on behavioral and brain measures, despite the presence of psychosis. This study provides evidence that (a) consideration of baseline levels of activation and synchrony will be essential for a comprehensive understanding of neural response differences in psychosis, and (b) distinct psychosis subgroups exhibit reduced versus augmented intrinsic neural activity, despite cognitive performance and clinical similarities.

AB - Individuals with psychosis have been reported to show either reduced or augmented brain responses under seemingly similar conditions. It is likely that inconsistent baseline-adjustment methods are partly responsible for this discrepancy. Using steady-state stimuli during a pro/antisaccade task, this study addressed the relationship between nonspecific and stimulus-related neural activity, and how these activities are modulated as a function of cognitive demands. In 98 psychosis probands (schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis), neural activity was assessed during baseline and during a 5-s period in preparation for the pro/antisaccade task. To maximize the ability to identify meaningful differences between psychosis subtypes, analyses were conducted as a function of subgrouping probands by standard clinical diagnoses and neurobiological features. These psychosis "biotypes" were created using brain-based biomarkers, independent of symptomatology (Clementz et al., ). Psychosis probands as a whole showed poor antisaccade performance and diminished baseline oscillatory phase synchrony. Psychosis biotypes differed on both behavioral and brain measures, in ways predicted from Clementz et al. (). Two biotype groups showed similarly deficient behavior and baseline synchrony, despite diametrically opposed neural activity amplitudes. Another biotype subgroup was more similar to healthy individuals on behavioral and brain measures, despite the presence of psychosis. This study provides evidence that (a) consideration of baseline levels of activation and synchrony will be essential for a comprehensive understanding of neural response differences in psychosis, and (b) distinct psychosis subgroups exhibit reduced versus augmented intrinsic neural activity, despite cognitive performance and clinical similarities.

KW - Biomarkers

KW - Bipolar disorder

KW - Diagnosis

KW - EEG

KW - Psychosis

KW - Schizophrenia

KW - Steady-state

UR - http://www.scopus.com/inward/record.url?scp=85017568309&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017568309&partnerID=8YFLogxK

U2 - 10.1111/psyp.12875

DO - 10.1111/psyp.12875

M3 - Article

C2 - 28419491

AN - SCOPUS:85017568309

JO - Psychophysiology

JF - Psychophysiology

SN - 0048-5772

ER -