Intrinsic plasticity: An emerging player in addiction

Saïd Kourrich, Donna J. Calu, Antonello Bonci

Research output: Contribution to journalArticle

74 Scopus citations


Exposure to drugs of abuse, such as cocaine, leads to plastic changes in the activity of brain circuits, and a prevailing view is that these changes play a part in drug addiction. Notably, there has been intense focus on drug-induced changes in synaptic excitability and much less attention on intrinsic excitability factors (that is, excitability factors that are remote from the synapse). Accumulating evidence now suggests that intrinsic factors such as K + channels are not only altered by cocaine but may also contribute to the shaping of the addiction phenotype.

Original languageEnglish (US)
Pages (from-to)173-184
Number of pages12
JournalNature Reviews Neuroscience
Issue number3
Publication statusPublished - Feb 20 2015


ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

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