Intrinsic Variable Learning for Brain-Machine Interface Control by Human Anterior Intraparietal Cortex

Sofia Sakellaridi, Vassilios N. Christopoulos, Tyson Aflalo, Kelsie W. Pejsa, Emily R. Rosario, Debra Ouellette, Nader Pouratian, Richard A. Andersen

Research output: Contribution to journalArticlepeer-review

Abstract

Although animal studies provided significant insights in understanding the neural basis of learning and adaptation, they often cannot dissociate between different learning mechanisms due to the lack of verbal communication. To overcome this limitation, we examined the mechanisms of learning and its limits in a human intracortical brain-machine interface (BMI) paradigm. A tetraplegic participant controlled a 2D computer cursor by modulating single-neuron activity in the anterior intraparietal area (AIP). By perturbing the neuron-to-movement mapping, the participant learned to modulate the activity of the recorded neurons to solve the perturbations by adopting a target re-aiming strategy. However, when no cognitive strategies were adequate to produce correct responses, AIP failed to adapt to perturbations. These findings suggest that learning is constrained by the pre-existing neuronal structure, although it is possible that AIP needs more training time to learn to generate novel activity patterns when cognitive re-adaptation fails to solve the perturbations. Sakellaridi, Christopoulos, et al. studied the learning mechanism in human AIP using brain-machine interface paradigms. They found that changes in neural activity during learning reflect cognitive re-adaptation mechanisms. When cognitive strategies were not adequate for compensation, AIP failed to learn.

Original languageEnglish (US)
Pages (from-to)694-705.e3
JournalNeuron
Volume102
Issue number3
DOIs
StatePublished - May 8 2019
Externally publishedYes

Keywords

  • anterior intraparietal cortex
  • brain-machine interface
  • individual-neuron learning
  • intrinsic-variable learning
  • posterior parietal cortex
  • spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)

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