Invasive lobular carcinoma of the breast: Mammographic characteristics and computer-aided detection

W. Phil Evans, Linda J Warren Burhenne, Louba Laurie, Kathryn F. O'Shaughnessy, Ronald A. Castellino

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

PURPOSE: To characterize the mammographic appearance of invasive lobular carcinoma in a large series of screening-detected consecutive breast cancers and to evaluate the ability of a computer-aided detection system to mark these carcinomas. MATERIALS AND METHODS: Investigators used the Breast Imaging Reporting and Data System lexicon to characterize lesions as part of a retrospective review of 90 screening mammographic examinations that led to biopsy-proved diagnosis of 94 invasive lobular carcinoma lesions. The 40 available prior mammographic examinations (obtained 9-24 months earlier) were also reviewed to characterize any visible findings. The results of a computer-aided detection analysis were compared with the images, and the sensitivity of the algorithm was calculated for correct detection of the lesions. RESULTS: Fifty-six (60%) of 94 lesions manifested as masses, of which 40 (71%) were described as irregular and spiculated; 20 (21%) of 94, as architectural distortions; and the remainder, 18 (20%), as either asymmetric densities or calcifications. On the screening mammograms showing biopsy-proved cancers, the sensitivity of the computer-aided detection system was 86 (91%) of 94 lesions. Thirty-one of the 40 prior mammograms showed retrospectively visible findings, and 24 (77%) of 31 were marked by the computer-aided detection system. CONCLUSION: Spiculated masses and architectural distortions are the predominant appearances of invasive lobular carcinoma, and a computer-aided detection system correctly marked a high percentage of invasive lobular carcinoma lesions.

Original languageEnglish (US)
Pages (from-to)182-189
Number of pages8
JournalRadiology
Volume225
Issue number1
StatePublished - Oct 1 2002

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Lobular Carcinoma
Breast
Biopsy
Information Systems
Research Personnel
Breast Neoplasms
Carcinoma
Neoplasms

Keywords

  • Breast neoplasms, diagnosis
  • Breast neoplasms, radiography
  • Brest radiography
  • Computers, diagnostic aid

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Evans, W. P., Burhenne, L. J. W., Laurie, L., O'Shaughnessy, K. F., & Castellino, R. A. (2002). Invasive lobular carcinoma of the breast: Mammographic characteristics and computer-aided detection. Radiology, 225(1), 182-189.

Invasive lobular carcinoma of the breast : Mammographic characteristics and computer-aided detection. / Evans, W. Phil; Burhenne, Linda J Warren; Laurie, Louba; O'Shaughnessy, Kathryn F.; Castellino, Ronald A.

In: Radiology, Vol. 225, No. 1, 01.10.2002, p. 182-189.

Research output: Contribution to journalArticle

Evans, WP, Burhenne, LJW, Laurie, L, O'Shaughnessy, KF & Castellino, RA 2002, 'Invasive lobular carcinoma of the breast: Mammographic characteristics and computer-aided detection', Radiology, vol. 225, no. 1, pp. 182-189.
Evans WP, Burhenne LJW, Laurie L, O'Shaughnessy KF, Castellino RA. Invasive lobular carcinoma of the breast: Mammographic characteristics and computer-aided detection. Radiology. 2002 Oct 1;225(1):182-189.
Evans, W. Phil ; Burhenne, Linda J Warren ; Laurie, Louba ; O'Shaughnessy, Kathryn F. ; Castellino, Ronald A. / Invasive lobular carcinoma of the breast : Mammographic characteristics and computer-aided detection. In: Radiology. 2002 ; Vol. 225, No. 1. pp. 182-189.
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