Abstract
Herein, we report a rare case of invasive Paget disease of the nipple with axillary-lymph-node metastasis in a 60-year-old white woman. The patient had intermittent, bloody nipple discharge without skin changes of the nipple-areolar region. We considered the clinical diagnosis of intraductal papilloma. A subareolar core biopsy revealed invasive ductal carcinoma in deep dermal tissue without the overlying epidermis biopsied. The patient underwent total mastectomy and axillary sentinel lymph-node biopsy that demonstrated invasive Paget disease of the nipple with 3.5-mm depth of invasion, ductal carcinoma in-situ in the underlying breast parenchyma, and macrometastasis (5.0 mm) in the sentinel lymph node. Prognostic marker studies of the metastatic site revealed a profile similar to that in the invasive mammary Paget disease (estrogen receptor [ER]+/progesterone receptor [PR]+/ human epidermal growth factor receptor 2 [HER2]-/ proliferation index [Ki-67] of 30%). The patient received adjuvant chemotherapy and experienced no disease recurrence at 20-months of follow-up. This case of luminal-B subtype invasive Paget disease as the source of regional metastasis is unique in the literature, to our knowledge.
Original language | English (US) |
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Pages (from-to) | 332-337 |
Number of pages | 6 |
Journal | Laboratory medicine |
Volume | 46 |
Issue number | 4 |
DOIs | |
State | Published - Nov 1 2015 |
Keywords
- Breast
- Carcinoma
- Invasive
- Mammary
- Nipple
- Paget disease
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical