Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA)

John J. Strouse, Christiane S. Cox, Elias R. Melhem, Hanzhang Lu, Michael A. Kraut, Alexander Razumovsky, Kaleb Yohay, Peter C. Van Zijl, James F. Casella

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Abstract

Overt stroke, clinically "silent" cerebral infarct, and neurocognitive impairment are frequent complications of sickle cell anemia (SCA). Current imaging techniques have limited sensitivity and specificity to identify children at risk for neurocognitive impairment. We prospectively evaluated 24 children with SCA with a neurologic exam, complete blood count, transcranial Doppler ultrasound (TCD), measurement of intelligence quotient (IQ), and magnetic resonance imaging (MRI) with measurement of cerebral blood flow (CBF) using continuous arterial spinlabeling (CASL) MRI. Average CBF to gray matter was 112 ± 36 mL/100 g/min. We identified a strong inverse relationship between performance IQ and CBF (-1.5 points per 10 mL/100 g/min increase in CBF, P = .013). Elevated steady-state white blood cell count (≤ 14 = 109/L [14 000/μL]) was associated with lower full scale IQ (86 ± 9 vs 99 ± 10, P ± .005). CASL MRI may identify children with neurocognitive impairment, before damage is evident by structural MRI or TCD.

Original languageEnglish (US)
Pages (from-to)379-381
Number of pages3
JournalBlood
Volume108
Issue number1
DOIs
StatePublished - Jul 1 2006

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Cerebrovascular Circulation
Sickle Cell Anemia
Magnetic resonance
Labeling
Blood
Intelligence
Magnetic Resonance Imaging
Imaging techniques
Doppler Ultrasonography
Blood Cell Count
Ultrasonics
Leukocyte Count
Nervous System
Stroke
Sensitivity and Specificity
Cells

ASJC Scopus subject areas

  • Hematology

Cite this

Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA). / Strouse, John J.; Cox, Christiane S.; Melhem, Elias R.; Lu, Hanzhang; Kraut, Michael A.; Razumovsky, Alexander; Yohay, Kaleb; Van Zijl, Peter C.; Casella, James F.

In: Blood, Vol. 108, No. 1, 01.07.2006, p. 379-381.

Research output: Contribution to journalArticle

Strouse, John J. ; Cox, Christiane S. ; Melhem, Elias R. ; Lu, Hanzhang ; Kraut, Michael A. ; Razumovsky, Alexander ; Yohay, Kaleb ; Van Zijl, Peter C. ; Casella, James F. / Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA). In: Blood. 2006 ; Vol. 108, No. 1. pp. 379-381.
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